Reduced serum pyridoxine and 25-hydroxyvitamin D levels in adults with chronic pruritic dermatoses.
Reduced serum pyridoxine and 25-hydroxyvitamin D levels in adults with chronic pruritic dermatoses.
复制标题
患有慢性瘙痒性皮肤病的成人血清吡哆醇和 25-羟基维生素 D 水平降低。
DOI：
10.1007/s00403-022-02357-9
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发表时间：
2023
影响因子：
3
通讯作者：
Kwatra,
中科院分区：
文献类型：
--
作者：
Gopinath,Shilpa;Sutaria,Nishadh;Bordeaux,ZacharyA;Parthasarathy,Varsha;Deng,Junwen;Taylor,MatthewT;Marani,Melika;Lee,Kevin;Pritchard,Thomas;Alajmi,Ali;Adawi,Waleed;Oladipo,OlusolaO;Semenov,YevgeniyR;Alphonse,Martin;Kwatra,
营养因素在慢性皮炎（CPD）发病机制中的作用知之甚少。在这项研究中，我们分析了CPD患者与匹配对照组相比的营养缺乏。我们从2005年至2006年的国家健康和营养检查调查（NHANES）中进行了一项基于人群的研究。该研究的主要结果是对CPD问卷回答肯定的参与者以及匹配的健康对照者的血清维生素水平的实验室数据。我们在美国9817名20至59岁的成年人中发现了877例CPD病例。与健康对照组相比，低维生素B6（OR 0.697; 95%CI：0.696- 0.699，p = 0.025）和维生素D（OR 0.794; 95%CI：0.789- 0.799，p = 0.037）水平与较高的CPD发生率相关。我们的研究表明，低水平的维生素B6和维生素D与CPD的存在呈负相关。这些维生素缺乏症表明，进一步研究维生素补充剂的作用可能有助于CPD患者。
Little is known about the role nutritional factors play in the pathogenesis of chronic pruritic dermatoses (CPD). In this study, we analyzed nutritional deficiencies in CPD patients compared to matched controls. We conducted a population-based study from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2006. The main outcomes of the study were laboratory data on serum vitamin levels in participants who answered affirmatively to the questionnaires on CPD as well as matched healthy controls. We identified 877 cases of CPD among 9817 adults in the US aged 20 to 59 years. These findings revealed a slightly higher percentage of females with CPD. Low vitamin B6 (OR 0.697; 95% CI: 0.696–0.699,p= 0.025) and vitamin D (OR 0.794; 95% CI: 0.789–0.799,p= 0.037) levels were associated with a higher rate of CPD compared to healthy controls. Our study suggests that low levels of Vitamin B6 and Vitamin D inversely correlates with the presence of CPD. These vitamin deficiencies suggest further studies on the effect of vitamin supplementation may help in patients with CPD.