PSORIASIS INDUCED BY INTERFERON-ALPHA
PSORIASIS INDUCED BY INTERFERON-ALPHA
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DOI：
10.1111/j.1365-2133.1991.tb14774.x
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发表时间：
1991-11-01
影响因子：
10.3
通讯作者：
HANSSEN, LE
中科院分区：
文献类型：
--
作者：
FUNK, J;LANGELAND, T;HANSSEN, LE
重组人干扰素-α已被用于治疗几种癌症，但有几份报告称，它可能会加剧银屑病或引发其发作。我们报告了四名患者，其中三人首先发展银屑病和一个谁有一个恶化的条件在治疗干扰素-α。其中3名患者患有类癌综合征，1名患者患有肾癌，所有患者均接受干扰素-α-2b或2a（IFN-α-2b，2a）治疗，剂量范围为每日1.5 × 10（6）U至每周3次18 × 10（6）U。在两名患者中，银屑病的严重程度与干扰素的剂量之间似乎存在相关性。
Recombinant human interferon-alpha has been used in the treatment of several cancers, but there have been several reports that it may exacerbate psoriasis or trigger off its onset. We report four patients, three of whom first developed psoriasis and one who had an aggravation of the condition during treatment with interferon-alpha. Three of the patients had the carcinoid syndrome and one a renal carcinoma, and all were treated with interferon-alpha-2b or 2a (IFN-alpha-2b, 2a) with doses ranging from 1.5 x 1O(6) U daily to 18 x 10(6) U three times weekly. In two of the patients there appeared to be a correlation between the severity of the psoriasis and the dosage of interferon.