ENHANCED RESISTANCE AGAINST ENCEPHALOMYOCARDITIS VIRUS-INFECTION IN MICE, INDUCED BY A NONVIABLE MYCOBACTERIUM-TUBERCULOSIS OIL-DROPLET VACCINE
ENHANCED RESISTANCE AGAINST ENCEPHALOMYOCARDITIS VIRUS-INFECTION IN MICE, INDUCED BY A NONVIABLE MYCOBACTERIUM-TUBERCULOSIS OIL-DROPLET VACCINE
复制标题
DOI：
10.1128/iai.19.1.225-230.1978
复制
发表时间：
1978-01-01
影响因子：
3.1
通讯作者：
EWALT, LC
中科院分区：
文献类型：
--
作者：
LODMELL, DL;EWALT, LC
Female C57B1/10 mice injected i.v. with nonviable M. tuberculosis Jamaica cells associated with oil-droplet emulsions (WCV) were highly resistant to the i.v. injection of encephalomyocarditis virus (EMCV). Resistance to infection (87% survival) was detected from 1 wk to at least 12 wk after injection of WCV. Mice vaccinated i.v. also were resistant to i.p., s.c. or i.m. virus challenge, but were not resistant to intracranial challenge. Mice vaccinated i.p. also were resistant to virus infection, whereas WCV administered i.m. or s.c. did not protect mice from virus injected by any route. Less than 50% of WCV mice that survived virus challenge possessed serum anti-EMCV-neutralizing antibody (< 1:10), and none had detectable (< 1:10) serum interferon. Interferon was not detected in sera of WCV mice from 4-144 h after i.v. injection of EMCV. Studies concerning the effects of WCV on EMCV infection suggest that mice may be protected by mechanisms that inhibit early viral replication and spread of virus to the CNS.
