Lethal action of quinolones against a temperature-sensitive dnaB replication mutant of Escherichia coli.
Lethal action of quinolones against a temperature-sensitive dnaB replication mutant of Escherichia coli.
复制标题
喹诺酮类药物对大肠杆菌温度敏感 dnaB 复制突变体的致死作用。
DOI：
10.1128/aac.50.1.362-364.2006
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Drlica,Karl
中科院分区：
文献类型：
--
作者：
Zhao,Xilin;Malik,Muhammad;Chan,Nymph;Drlica-Wagner,Alex;Wang,Jian-Ying;Li,Xinying;Drlica,Karl
Inhibition of DNA replication in anEscherichia coli dnaB-22mutant failed to block quinolone-mediated lethality. Inhibition of protein synthesis by chloramphenicol inhibited nalidixic acid lethality and, to a lesser extent, ciprofloxacin lethality in bothdnaB-22and wild-type cells. Thus, major features of quinolone-mediated lethality do not depend on ongoing replication.
