Macrophage colony-stimulating factor and the enhanced migration of monocytes are essential in primary but not secondary host defenses to Listeria organisms.
Macrophage colony-stimulating factor and the enhanced migration of monocytes are essential in primary but not secondary host defenses to Listeria organisms.
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巨噬细胞集落刺激因子和单核细胞迁移的增强对于宿主对李斯特菌的初级防御至关重要，但不是次级防御。
DOI：
10.1093/infdis/168.4.934
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Wing,EJ
中科院分区：
文献类型：
--
作者：
Gregory,SH;Wing,EJ
非免疫小鼠感染单核细胞增生李斯特菌后，巨噬细胞集落刺激因子（M-CSF）mRNA表达增加，骨髓来源的单核巨噬细胞（BMMP）向肝脏的迁移增强。用抗M-CSF单克隆抗体治疗可减少BMMP的运输，促进Escheriae的复制。免疫动物感染的马立克氏体表达的M-CSF mRNA水平显着低于非免疫动物。此外，病毒感染并不引起BMMP迁移到免疫小鼠的肝脏，抗M-CSF也不影响免疫动物对感染的反应能力。连续免疫实验表明，在M-CSF和迁移性BMMP缺乏的情况下，T淋巴细胞可以介导对Escherichia coli的保护性免疫。这些发现表明，M-CSF和BMMP迁移的增强是宿主对病毒感染的主要防御而不是次要防御的关键因素。
Nonimmune mice infected withListeria monocytogenesexhibited elevated expression of macrophage colony-stimulating factor (M-CSF) mRNA and the enhanced migration of Mac-l antigen- positive bone marrow-derived mononuclear phagocytes (BMMP) to their livers. Treatment with monoclonal anti-M-CSF antibody diminished the traffic of BMMP and promoted the replication of listeriae. Immune animals infected with listeriae expressed significantly lower levels of M-CSF mRNA than did nonimmune animals. Moreover, listerial infections did not elicit the migration of BMMP to the livers of immune mice, nor did anti-M-CSF affect the capacity of immune animals to respond to infection. Adoptive immunization experiments suggest that T lymphocytes can mediate protective immunity to listeriae in the absence of M-CSF and migrating BMMP. These findings indicate that M-CSF and the enhanced migration of BMMP are critical factors in primary but not secondary host defenses to listerial infections.