AMINE AND PEPTIDE-HORMONE PRODUCTION BY LUNG CARCINOID - A CLINICOPATHOLOGICAL AND IMMUNOCYTOCHEMICAL STUDY
AMINE AND PEPTIDE-HORMONE PRODUCTION BY LUNG CARCINOID - A CLINICOPATHOLOGICAL AND IMMUNOCYTOCHEMICAL STUDY
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DOI：
10.1136/jcp.37.8.931
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发表时间：
1984-01-01
影响因子：
3.4
通讯作者：
CRAMERKNIJNENBURG, G
中科院分区：
文献类型：
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作者：
BOSMAN, FT;DELARIVIERE, AB;CRAMERKNIJNENBURG, G
连续系列的38个肺类癌肿瘤（36个手术标本和2个尸检标本）进行了研究。组织学特征和胺和肽类激素免疫反应性与大体特征（大小，位置）和临床数据相关。外周类癌比中央类癌晚十年被检测到，并且往往更大。一般来说，周围型和中央型类癌的组织学特征是相似的，但是，非典型特征在周围型类癌中更为常见。大多数类癌含有许多嗜银细胞（58%）。虽然没有发现嗜银细胞，但32%的肿瘤中存在5-羟色胺免疫反应细胞。肽激素免疫反应性（促肾上腺皮质激素，降钙素，生长抑素，胃泌素）是罕见的。在1例病例中，大量ACTH产生引起临床表现的库兴综合征。另外2例ACTH免疫反应阳性细胞较少，1例降钙素免疫反应阳性细胞。肺类癌中激素产生的相对罕见和肿瘤的主要良性过程排除了使用肽激素产生作为预后指标。
A consecutive series of 38 lung carcinoid tumors (36 surgical and 2 necropsy specimens) was studied. Histopathological features and amine and peptide hormone immunoreactivity were correlated with gross characteristics (size, location) and clinical data. Peripheral carcinoids were detected a decade later than central carcinoids and tended to be bigger. In general, the histological characteristics of peripheral and central carcinoids were similar; atypical features, however, were more common in peripheral carcinoids. Most carcinoids contained many argyrophilic cells (58%). Although argentaffinic cells were not found, serotonin immunoreactive cells were present in 32% of the tumors. Peptide hormone immunoreactivity (ACTH, calcitonin, somatostatin, gastrin) was rare. In 1 case massive ACTH production had caused clinically manifest Cushing''s syndrome. In 2 other cases few ACTH immunoreactive cells were found and in 1 case calcitonin immunoreactive cells were present. The relative rarity of hormone production in lung carcinoids and the predominantly benign course of the tumor preclude the use of peptide hormone production as a prognostic indicator.