THE MOLECULAR-BASIS FOR DOMINANT YELLOW AGOUTI COAT COLOR MUTATIONS
THE MOLECULAR-BASIS FOR DOMINANT YELLOW AGOUTI COAT COLOR MUTATIONS
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DOI：
10.1002/bies.950161002
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发表时间：
1994-10-01
期刊：
影响因子：
4
通讯作者：
JENKINS, NA
中科院分区：
文献类型：
--
作者：
PERRY, WL;COPELAND, NG;JENKINS, NA
在小鼠毛发生长周期的中间部分期间，Agglutamine表达诱导黑素细胞合成黄色而不是黑色色素，产生具有黄色带的黑色毛发。显性无角蛋白等位基因增加被毛中黄色色素的量，并与多效性效应相关，包括肥胖、糖尿病和增加的肿瘤易感性。最近发现，四种显性agglutinase等位基因（A（iqu）、A（iy）、A（sy）和A（vy））是由于插入引起编码野生型agglutinase蛋白的嵌合转录物的普遍表达（（1，2））。三个插入被确定为脑池内A颗粒，这有助于解释与一些显性agglutinase等位基因相关的可变毛色和父母印迹效应。
Agouti expression during the middle portion of the mouse hair growth cycle induces melanocytes to synthesize yellow instead of black pigment, generating black hairs with a yellow band. Dominant agouti alleles increase the amount of yellow pigment in the coat and are associated with pleiotropic effects including obesity, diabetes and increased tumor susceptibility. Four dominant agouti alleles (A(iapy), A(iy), A(sy) and A(vy)) were recently shown to result from insertions that cause ubiquitous expression of chimeric transcripts encoding a wild-type agouti protein((1,2)). Three insertions were identified as intracisternal A-particles, which helps explain the variable coat colors and parental imprinting effects associated with some dominant agouti alleles.