Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial
Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial
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DOI：
10.1152/ajpendo.00495.2010
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发表时间：
2011-01-01
影响因子：
5.1
通讯作者：
Stener-Victorin, Elisabet
中科院分区：
文献类型：
--
作者：
Jedel, Elizabeth;Labrie, Fernand;Stener-Victorin, Elisabet
Jedel E，Labrie F，Oden A，霍尔姆G，Nilsson L，Janson PO，Lind A，Ohlsson C，Stener-Victorin E.电针和体育锻炼对多囊卵巢综合征女性高雄激素血症和少/闭经的影响：一项随机对照试验Am J Physiol Endocrinol Metab 300：E37-E45，2011.首次发表于2010年10月13日; doi：10.1152/ajpendo.00495.2010.-多囊卵巢综合征（PCOS）是育龄期女性最常见的内分泌疾病，以高雄激素血症、少经/闭经和多囊卵巢为特征。我们的目的是确定低频电针（EA）是否会降低高雄激素血症和改善少/闭经更有效地比体育锻炼或没有干预。我们将84名年龄在18-37岁的多囊卵巢综合征妇女随机分为三组，一组接受16周的低频电针治疗，另一组进行体育锻炼，或者不进行任何干预。通过意向治疗分析了第16周时通过气相和液相色谱-质谱法测定的总睾酮（T）浓度的主要结果指标变化。次要结果指标为月经频率的变化;雄激素、雌激素、雄激素前体和葡萄糖醛酸化雄激素代谢物的浓度;以及痤疮和多毛症。在基线、16周干预后和16周随访后评估结果。干预16周后，EA组循环T下降-25%，雄甾酮葡萄糖醛酸苷下降-30%，雄甾烷-3 α，17 β-二醇-3-葡萄糖醛酸苷下降-28（与运动相比，P分别为0.038、0.030和0.047）; EA组的月经频率从基线时的0.28次增加到0.69次/月（P = 0.018 vs.锻炼）。16周随访后，EA组的痤疮评分下降了-32%（P = 0.006 vs.运动）。在第16周和第16周随访时，与未进行干预相比，EA和运动均改善了月经频率，降低了几种性类固醇的水平。低频电针和体育锻炼改善高雄激素血症和月经频率更有效地比没有干预PCOS妇女。低频电针治疗高雄激素血症和少/闭经上级优于体育锻炼。
Jedel E, Labrie F, Oden A, Holm G, Nilsson L, Janson PO, Lind A, Ohlsson C, Stener-Victorin E. Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial. Am J Physiol Endocrinol Metab 300: E37-E45, 2011. First published October 13, 2010; doi:10.1152/ajpendo.00495.2010.-Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, is characterized by hyperandrogenism, oligo/amenorrhea, and polycystic ovaries. We aimed to determine whether low-frequency electro-acupuncture (EA) would decrease hyperandrogenism and improve oligo/amenorrhea more effectively than physical exercise or no intervention. We randomized 84 women with PCOS, aged 18-37 yr, to 16 wk of low-frequency EA, physical exercise, or no intervention. The primary outcome measure changes in the concentration of total testosterone (T) at week 16 determined by gas and liquid chromatography- mass spectrometry was analyzed by intention to treat. Secondary outcome measures were changes in menstrual frequency; concentrations of androgens, estrogens, androgen precursors, and glucuronidated androgen metabolites; and acne and hirsutism. Outcomes were assessed at baseline, after 16 wk of intervention, and after a 16-wk follow-up. After 16 wk of intervention, circulating T decreased by -25%, androsterone glucuronide by -30%, and androstane-3 alpha,17 beta-diol-3-glucuronide by -28% in the EA group (P = 0.038, 0.030, and 0.047, respectively vs. exercise); menstrual frequency increased to 0.69/month from 0.28 at baseline in the EA group (P = 0.018 vs. exercise). After the 16-wk follow-up, the acne score decreased by -32% in the EA group (P = 0.006 vs. exercise). Both EA and exercise improved menstrual frequency and decreased the levels of several sex steroids at week 16 and at the 16-wk follow-up compared with no intervention. Low-frequency EA and physical exercise improved hyperandrogenism and menstrual frequency more effectively than no intervention in women with PCOS. Low-frequency EA was superior to physical exercise and may be useful for treating hyperandrogenism and oligo/amenorrhea.