Apolipoprotein E Levels in Pediatric Patients Undergoing Cardiopulmonary Bypass
Apolipoprotein E Levels in Pediatric Patients Undergoing Cardiopulmonary Bypass
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DOI：
10.1111/aor.12444
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发表时间：
2015-01-01
影响因子：
2.4
通讯作者：
Uendar, Akif
中科院分区：
文献类型：
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作者：
Agirbasli, Mehmet;Song, Jianxun;Uendar, Akif
载脂蛋白E（apoE）可能在调节儿童体外循环（CPB）后神经损伤的反应中起关键作用。从38名儿科患者中采集血浆样本。一半的患者接受非脉动流，另一半在CPB期间接受脉动流。分别于术前（T1）、CPB后1 h（T2）、CPB后24 h（T3）采集血浆标本。该研究包括38名接受心脏手术的儿科患者（平均年龄2.5 ± 2.1岁）。基线apoE水平较低（
Apolipoprotein E (apoE) may play a critical role in modulating the response to neurological injury after cardiopulmonary bypass (CPB) in children. Plasma samples were collected from 38 pediatric patients. Half of the patients received nonpulsatile flow and the other half underwent pulsatile flow during CPB. Plasma samples were collected at three time points: at baseline prior to incision (T1), 1h after CPB (T2), and 24h after CPB (T3). The study included 38 pediatric patients undergoing heart surgery (mean age 2.5 +/- 2.1 years). Baseline apoE levels were low (