EFFECTS OF THE HUMAN INTESTINAL FLORA ON GERMFREE-MICE
EFFECTS OF THE HUMAN INTESTINAL FLORA ON GERMFREE-MICE
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DOI：
10.1111/j.1365-2672.1981.tb00874.x
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
VERSCHOORBURGGRAAF, A
中科院分区：
文献类型：
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作者：
HAZENBERG, MP;BAKKER, M;VERSCHOORBURGGRAAF, A
研究了完整的人类肠道菌群和肠道厌氧菌对无菌小鼠的影响。小鼠菌群的总体组成与动物被污染的菌群相似，并且在动物保持隔离的情况下似乎是稳定的。完整的菌群和厌氧菌将盲肠重量降至正常值，并诱导对大肠杆菌的拮抗作用。与完整菌群相比，厌氧菌在免疫抑制小鼠中不具有侵袭性，并诱导对铜绿假单胞菌的定植抵抗和拮抗作用。
The effects of complete human intestinal flora and of intestinal anaerobes on germ-free mice were studied. The gross composition of the flora of mice was similar to that of the flora with which the animals had been contaminated and appeared to be stable provided that the animals were kept isolated. The complete flora and the anaerobes reduced cecal weight to normal values and induced an antagonistic effect against Escherichia coli. In contrast to the complete flora, the anaerobes were not invasive in immunosuppressed mice and induced colonization resistance and antagonism against Pseudomonas aeruginosa.