The association between chronic psychosocial stress, allostatic load, and vascular health in asymptomatic young men : A pilot study using a novel finger arterial stiffness index
The association between chronic psychosocial stress, allostatic load, and vascular health in asymptomatic young men : A pilot study using a novel finger arterial stiffness index
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无症状年轻男性慢性心理社会压力、稳态负荷和血管健康之间的关联：使用新型手指动脉僵硬度指数的初步研究
DOI：
10.1111/j.1468-5884.2011.00461.x
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发表时间：
2011
期刊：
影响因子：
0.8
通讯作者：
Sawada Y
中科院分区：
文献类型：
--
作者：
Tanana G;Kato Y;Matsumura K;Horiguchi M;Ogasawara H;Sawada Y
一种新的手指动脉僵硬度指数（FSI）与临床前心血管疾病风险标志物的关系进行了测试。此外，我们在37名年龄为24.8 ± 4.0岁的健康年轻男性中检查了心理社会因素与FSI之间的关联是否可以用非稳态负荷标记物来解释。 FSI是基于手指动脉压-容量关系的指数模型设计的。非稳态负荷指数（ALI）作为累积风险标志物，由9个变量的标准评分平均值定义：静息收缩压和舒张压、腰臀比、高密度脂蛋白胆固醇（HDL-C）、总胆固醇/HDL-C比值、甘油三酯、血红蛋白A1 c、胰岛素抵抗和高敏C反应蛋白（CRP）。FSI与HDL-C（r=-0.36）、CRP（r= 0.39）、ALI（r= 0.40）、不健康的整体饮食习惯（r= 0.34）、Buss-佩里攻击问卷中的敌意（r= 0.38）和一致性意识中的敌意（r=-0.38）之间的偏相关性在控制年龄后显著。 总之，FSI似乎与血管促炎症以及整体生理失调和非稳态负荷有关。这些关联受到饮食生活方式和心理社会压力的调节。
A novel index of finger arterial stiffness (FSI) was tested in terms of the relationship with risk markers for preclinical cardiovascular disease. In addition, we examined if the association between psychosocial factors and FSI was explained by allostatic load markers in 37 healthy young men aged 24.8 ± 4.0 years. The FSI was devised based on an exponential model of the finger arterial pressure‐volume relationship. The allostatic load index (ALI) as a cumulative risk marker was defined by the mean of standard scores for nine variables: resting systolic and diastolic blood pressure, waist/hip ratio, high‐density lipoprotein cholesterol (HDL‐C), total cholesterol/HDL‐C ratio, triglycerides, hemoglobin A1c, insulin resistance, and high sensitivity C‐reactive protein (CRP). Partial correlations controlling for age were significant for FSI with HDL‐C (r= −.36), CRP (r= .39), ALI (r= .40), unhealthy overall eating habits (r= .34), hostility using the Buss‐Perry Aggression Questionnaire (r= .38), and manageability in Sense of Coherence (r= −.38). In conclusion, FSI seems to be associated with vascular proinflammation as well as with overall physiological dysregulation and allostatic load. These associations were moderated by eating lifestyle and psychosocial stress.