TEMPORAL FILTERING IN RETINAL BIPOLAR CELLS - ELEMENTS OF AN OPTIMAL COMPUTATION
TEMPORAL FILTERING IN RETINAL BIPOLAR CELLS - ELEMENTS OF AN OPTIMAL COMPUTATION
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DOI：
10.1016/s0006-3495(90)82463-2
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发表时间：
1990-11-01
影响因子：
3.4
通讯作者：
OWEN, WG
中科院分区：
文献类型：
--
作者：
BIALEK, W;OWEN, WG
最近的实验表明，暗适应的脊椎动物视觉系统可以对光子进行计数，其可靠性受到视杆光感受器本身暗噪声的限制。这表明负责信号处理的视网膜后续层几乎不会添加多余的噪声，并提取所有可用的信息。考虑到感光器的信号和噪声特性，这样一个最佳处理器的结构是什么样的？我们表明，随时间变化的光强度的最佳估计可以通过两级滤波器来完成，并且我们建议第一级应该与视网膜信号处理（信号从杆状感光器到双极细胞的信号传输）的第一解剖阶段发生的滤波相一致。这导致了双极细胞反应的无参数预测，这与在同一视网膜中比较视杆细胞和双极细胞动力学的实验非常一致。据我们所知，这是第一个可以预测而不是建模神经元的计算重要动态的情况。
Recent experiments indicate that the dark-adapted vertebrate visual system can count photons with a reliability limited by dark noise in the rod photoreceptors themselves. This suggests that subsequent layers of the retina, responsible for signal processing, add little if any excess noise and extract all the available information. Given the signal and noise characteristics of the photoreceptors, whan is the structure of such an optimal processor? We show that optimal estimates of time-varying light intensity can be accomplished by a two-stage filter, and we suggest that the first stage should be identified with the filtering which occurs at the first anatomical stage in retinal signal processing, signal transfer from the rod photoreceptor to the bipolar cell. This leads to parameter-free predictions of the bipolar cell response, which are excellent agreement with experiments comparing rod and bipolar cell dynamics in the same retina. As far as we know this is the first case in which the computationally significant dynamics of a neuron could be predicted rather than modeled.