Role of the Hedgehog pathway in hepatocellular carcinoma (review).
Role of the Hedgehog pathway in hepatocellular carcinoma (review).
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DOI：
10.3892/or.2013.2690
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发表时间：
2013-11
期刊：
影响因子：
4.2
通讯作者：
Xin Zheng;Wen-Long Zeng;X. Gai;Qiuran Xu;Chao Li;Zheyong Liang;Hang Tuo;Qingguang Liu
中科院分区：
文献类型：
--
作者：
Xin Zheng;Wen-Long Zeng;X. Gai;Qiuran Xu;Chao Li;Zheyong Liang;Hang Tuo;Qingguang Liu
Hedgehog（Hh）信号通路是一种进化上保守的信号传导机制，在胚胎发生过程中控制细胞分化和组织器官发育的许多方面。早期的研究集中在Hh活性对器官发育的影响，包括皮肤，肠道，神经系统和骨骼。然而，除了正常的发育过程，这些研究还发现，Hh信号参与异常增殖和恶性转化。因此，Hh在癌症病理学中的作用及其受环境因素的调节是许多研究的主题。许多环境毒素，酒精和肝炎病毒可导致肝细胞癌（HCC），这是最常见的肝癌形式。在肝损伤和肝硬化中已经观察到Hh信号的显著超活化，这通常导致HCC病变的发展。此外，Hh活性在HCC的进展中起重要作用。在这里，我们回顾了相关的研究结果，我们的理解Hh信号在肝癌发病机制中的作用。
The Hedgehog (Hh) pathway is an evolutionarily conserved signaling mechanism that controls many aspects of cell differentiation and the development of tissues and organs during embryogenesis. Early investigations have focused on the effects of Hh activity on the development of organs including skin, gut, the nervous system and bone. However, in addition to normal developmental processes, these investigations also found that Hh signaling is involved in aberrant proliferation and malignant transformation. Consequently, the role of Hh in cancer pathology, and its modulation by environmental factors is the subject of many investigations. Numerous environmental toxins, alcohol, and hepatitis viruses can cause hepatocellular carcinoma (HCC), which is the most common form of liver cancer. Significant hyperactivation of Hh signaling has been observed in liver injury and cirrhosis which often leads to the development of HCC lesions. Moreover, Hh activity plays an important role in the progression of HCC. Here, we review findings relevant to our understanding of the role of Hh signaling in HCC pathogenesis.