Engrailed negatively regulates the expression of cell adhesion molecules connectin and neuroglian in embryonic Drosophila nervous system.
Engrailed negatively regulates the expression of cell adhesion molecules connectin and neuroglian in embryonic Drosophila nervous system.
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Engrailed 负向调节胚胎果蝇神经系统中细胞粘附分子连接蛋白和神经胶质细胞的表达。
DOI：
10.1016/s0896-6273(00)81088-0
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发表时间：
1999
期刊：
影响因子：
16.2
通讯作者：
Jia,XX
中科院分区：
文献类型：
--
作者：
Siegler,MV;Jia,XX
Engrailed在不表达连接蛋白或可感知的神经胶质细胞的中间神经元亚群中表达，而其他Engrailed阴性的神经元则强烈表达这些粘附分子。当连接蛋白和神经胶质细胞的表达在神经元中被普遍驱动时，连接蛋白和神经胶质细胞的表达在中间神经元中几乎被消除，而当突变胚胎中缺乏连接蛋白基因时，连接蛋白和神经胶质细胞的表达则大大增加。数据表明，Engrailed通常是康涅狄格和神经胶质细胞的负调节因子。这是最早在果蝇的神经系统中发现的两个“效应”基因，它们是Engrailed的调控靶标。我们认为，差异嵌入表达是决定细胞粘附分子表达模式的关键，因此构成了神经元形状和连接的重要决定因素。
Engrailed is expressed in subsets of interneurons that do not express Connectin or appreciable Neuroglian, whereas other neurons that are Engrailed negative strongly express these adhesion molecules. Connectin and Neuroglian expression are virtually eliminated in interneurons whenengrailedexpression is driven ubiquitously in neurons, and greatly increased whenengrailedgenes are lacking in mutant embryos. The data suggest that Engrailed is normally a negative regulator ofConnectinandneuroglian. These are the first two "effector" genes identified in the nervous system ofDrosophilaas regulatory targets for Engrailed. We argue that differential Engrailed expression is crucial in determining the pattern of expression of cell adhesion molecules and thus constitutes an important determinant of neuronal shape and perhaps connectivity.