Xth International Symposium on Insulin Receptors and Insulin Action
Xth International Symposium on Insulin Receptors and Insulin Action
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第十届国际胰岛素受体与胰岛素作用研讨会
DOI：
10.1111/j.1748-1716.2007.01796.x
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发表时间：
2007
影响因子：
6.3
通讯作者：
J. Zierath
中科院分区：
文献类型：
--
作者：
J. Zierath
生理学报的这期特刊包含了来自第X届胰岛素受体和胰岛素作用国际研讨会（http：//www. bokningsbolaget。se/congress/ki/ir 07），2007年5月2日至6日在瑞典斯德哥尔摩举行。该会议自1981年起每3年在欧洲举办一次，主要讨论与糖尿病、肥胖等代谢性疾病相关的胰岛素信号转导和代谢的基础和临床机制，但胰岛素信号转导和代谢的分子机制尚未完全解决。胰岛素信号转导元件的功能或结构异常被认为在糖尿病发病机制中起关键作用。这一领域的研究才刚刚开始解决这种复杂的代谢紊乱背后的机制。研讨会的主要重点是在控制胰岛素受体信号和行动的机制的最新发展。还强调了确定和验证糖尿病预防目标的新技术和研究方法。这一期的生理学报捕捉了研讨会讲座的亮点。在过去的十年中，在解决胰岛素受体与下游代谢和基因调控效应之间的复杂信号传导方面取得了巨大进展。科林·沃德（Colin Ward）介绍了他工作的最新进展，揭示了配体诱导的胰岛素受体激活的新结构见解。Melaine Cobb描述了她对蛋白激酶ERK 1/2及其在胰腺β细胞中的作用的研究。Anne Brunet强调了FOXO转录因子在衰老和癌症中的作用。这些评论涵盖了胰岛素受体的结构/功能和中间信号转录事件的方面。本期的几篇综述文章强调了代谢和炎症信号级联之间的“串扰”。例如，Emmanuel货车Obberghen强调了SOCS蛋白在胰岛素作用中的作用，安娜Krook回顾了白细胞介素-6对骨骼肌中信号转导和代谢的影响，
This special issue of Acta Physiologica contains review articles from symposium speakers at the Xth International Symposium on Insulin Receptors and Insulin Action(http://www. bokningsbolaget. se/congress/ki/ir07), which was held in Stockholm, Sweden, 2–6 May 2007. This symposium has been organized every 3 years in Europe since 1981 and has brought forward recent advances in the description of basic and clinical mechanisms of insulin signal transduction and metabolism related to metabolic diseases such as diabetes mellitus and obesity.The molecular mechanisms of insulin signal transduction and metabolism are incompletely resolved. Functional or structural abnormalities of insulin signal transduction elements are believed to play a pivotal role in diabetes pathogenesis. Research in this area is only just beginning to resolve the mechanisms behind this complex metabolic disorder. The major focus of the Symposium was on recent developments in mechanism controlling insulin receptor signalling and action. Emphasis was also placed on new technology and research approaches for the identification and validation of diabetes prevention targets. This issue of Acta Physiologica captures highlights of the symposium lectures. In the last decade there have been great strides in resolving the complex signalling between the insulin receptor and downstream metabolic and gene regulatory effects. Colin Ward presents an update on his work revealing novel structural insights into ligand-induced activation of the insulin receptor. Melaine Cobb describes her work on the protein kinases ERK1/2 and their roles in pancreatic beta cells. Anne Brunet highlights the role of FOXO transcription factors in ageing and cancer. These reviews cover aspects of insulin receptor structure/function and intermediate signalling to transcriptional events. Several review articles in this issue emphasize ‘crosstalk’between metabolic and inflammatory signalling cascades. For example, Emmanuel Van Obberghen highlights the role of SOCS proteins in insulin action, Anna Krook reviews the effects of interleukin-6 on signal transduction and metabolism in skeletal muscle,