A theory of joint attractor dynamics in the hippocampus and the entorhinal cortex accounts for artificial remapping and grid cell field-to-field variability
A theory of joint attractor dynamics in the hippocampus and the entorhinal cortex accounts for artificial remapping and grid cell field-to-field variability
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DOI：
10.7554/elife.56894
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发表时间：
2020-08-11
期刊：
影响因子：
7.7
通讯作者：
Burak, Yoram
中科院分区：
文献类型：
--
作者：
Agmon, Haggai;Burak, Yoram
哺乳动物大脑中位置的表征分布在多个神经种群中。内侧内嗅皮层(MEC)中的网格细胞模块表达跨越低维歧管的活动模式，该模式在不同环境中保持稳定。相反，在不同的环境中，海马区细胞的活动模式跨越不同的低维歧管。目前尚不清楚这些位置的多种表示是如何协调的。在这里，我们发展了一个关于海马区和MEC的联合吸引子动力学的理论。我们表明，该系统在多个环境中表现出协调的、联合的位置表示，与位置单元和网格单元中的全局重新映射一致。此外，我们的模型解释了最近的实验观察，这些实验观察缺乏机械解释：在MEC的第二层星状细胞的去极化而不是超极化的情况下，单个网格细胞的放电率的可变性，以及位置细胞的人工重新映射。
The representation of position in the mammalian brain is distributed across multiple neural populations. Grid cell modules in the medial entorhinal cortex (MEC) express activity patterns that span a low-dimensional manifold which remains stable across different environments. In contrast, the activity patterns of hippocampal place cells span distinct low-dimensional manifolds in different environments. It is unknown how these multiple representations of position are coordinated. Here, we develop a theory of joint attractor dynamics in the hippocampus and the MEC. We show that the system exhibits a coordinated, joint representation of position across multiple environments, consistent with global remapping in place cells and grid cells. In addition, our model accounts for recent experimental observations that lack a mechanistic explanation: variability in the firing rate of single grid cells across firing fields, and artificial remapping of place cells under depolarization, but not under hyperpolarization, of layer II stellate cells of the MEC.