On the examination of the viscous response of the brachial artery during flow-mediated dilation
On the examination of the viscous response of the brachial artery during flow-mediated dilation
复制标题
血流介导扩张过程中肱动脉粘性反应的检测
DOI：
10.1016/j.jmbbm.2022.105255
复制
发表时间：
2022
影响因子：
3.9
通讯作者：
Wu, Qianhong
中科院分区：
文献类型：
--
作者：
Sidnawi, Bchara;Santhanam, Sridhar;Sehgal, Chandra;Wu, Qianhong
在这项研究中，通过一个基于物理的粘弹性模型来研究机械转导，该模型描述了在肱动脉血流介导的扩张（BAFMD）测试中动脉直径的反应。该研究是两项早期研究的重要延伸，其中只考虑了弹性响应。实验收集了12名健康志愿者的BAFMD反应。将动脉壁的弹性和粘性特性视为局部变量，这取决于机械转导感知的壁剪应力。模型中产生的无量纲参数作为动脉物理状态的定量评估，被调整以复制实验反应。在这些无量纲参数中，反映粘性响应相对于弹性响应的相对强度的粘弹性比与本文的主要结论特别相关。结果表明，至少在BAFMD试验的严格背景下，动脉壁的力学行为主要是弹性的。对未来的研究和应用提出了建议。
In this study, mechanotransduction is investigated through a physics-based viscoelastic model describing the arterial diameter response during a brachial artery flow mediated dilation (BAFMD) test. The study is a significant extension of two earlier studies by the same group, where only the elastic response was considered. Experimental BAFMD responses were collected from 12 healthy volunteers. The arterial wall's elastic and viscous properties were treated as local variable quantities depending on the wall shear stress (WSS) sensed by mechanotransduction. The dimensionless parameters, arising from the model which serve as a quantitative assessment of the artery's physical state, were adjusted to replicate the experimental response. Among those dimensionless parameters, the viscoelastic ratio, which reflects the relative strength of the viscous response compared to its elastic counterpart, is of special relevance to this paper's main conclusion. Based on the results, it is concluded that the arterial wall's mechanical behavior is predominantly elastic, at least in the strict context of the BAFMD test. Recommendations for potential future research and applications are provided.