Primary in situ squamous cell carcinoma of the endometrium, with extensive squamous metaplasia and dysplasia.
Primary in situ squamous cell carcinoma of the endometrium, with extensive squamous metaplasia and dysplasia.
复制标题
原发性子宫内膜原位鳞状细胞癌，伴有广泛的鳞状化生和不典型增生。
DOI：
10.1016/s0090-8258(02)00105-1
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发表时间：
2003
影响因子：
4.7
通讯作者：
S. Haouet
中科院分区：
文献类型：
--
作者：
Y. Zidi;S. Bouraoui;K. Atallah;N. Kchir;S. Haouet
背景子宫内膜原发性鳞状细胞癌是非常罕见的。它已被描述为与子宫积脓，但其病因仍不清楚。病例：作者报告的情况下，75岁的妇女谁提出了盆腔疼痛和子宫积脓。在子宫内未发现肉眼可见的肿瘤;然而，注意到子宫内膜粘膜的广泛表皮化。显微镜检查结果与子宫内膜原发性原位鳞状细胞癌一致，伴有广泛鳞状化生和异型增生区域。子宫内膜病变和宫颈HPV抗原及DNA检测均为阴性。结论：这些结果支持鳞状化生的变化顺序，通过异型增生进展为癌作为一个可能的发病过程。然而，HPV的作用仍然不确定。
Background. Primary squamous cell carcinoma of the endometrium is exceedingly rare. It has been described in association with pyometra but its etiology is still unclear. CASE: The authors report the case of a 75-year-old woman who presented with pelvic pain and pyometra. No gross tumor was identified in the uterus; however, extensive epidermalization of the endometrial mucosa was noted. Microscopic findings were consistent with a primary in situ squamous carcinoma of the endometrium associated with extensive squamous metaplasia and areas of dysplasia. HPV antigen and DNA detection were negative in both the endometrial lesions and the cervix. CONCLUSIONS: These results support the sequence of change with squamous metaplasia, progressing through dysplasia to carcinoma as a possible pathogenetic process. HPV’s role, however, remains uncertain.