Allergies, variants in IL-4 and IL-4R alpha genes, and risk of pancreatic cancer.
Allergies, variants in IL-4 and IL-4R alpha genes, and risk of pancreatic cancer.
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发表时间：
2007
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通讯作者：
S. Olson;I. Orlow;J. Simon;D. Tommasi;P. Roy;S. Bayuga;E. Ludwig;A. Zauber;R. Kurtz
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作者：
S. Olson;I. Orlow;J. Simon;D. Tommasi;P. Roy;S. Bayuga;E. Ludwig;A. Zauber;R. Kurtz
背景：一些流行病学研究表明，过敏人群患胰腺癌的风险降低。虽然已经确定了在过敏反应中起关键作用的基因，但尚未研究这些基因的多态性与胰腺癌风险的关系。我们假设这些基因的变异与风险有关。方法：在一项以医院为基础的病例对照研究中，我们调查了过敏与胰腺癌的关系，共有405例病例和212例对照。在149例病例和135例对照的亚组中，我们研究了IL-4 （C-589T, G3017T）和IL-4R α (Gln576Arg)变异与过敏和胰腺癌风险的关系。结果：我们发现与过敏相关的胰腺癌风险降低，任何过敏的校正优势比为0.58 (95% CI 0.40-0.84)，花粉热的校正优势比为0.45 (95% CI 0.29-0.70)，动物的校正优势比为0.43 （95% CI 0.23-0.80）。研究中每个基因座的小等位基因与对照组中过敏风险的降低有关，这使我们假设它们与胰腺癌风险的增加有关。总体而言，所研究的基因型与胰腺癌风险之间没有关联。在对存在或不存在过敏的人群进行的分析中，与IL-4 G3017T基因型相关的风险存在差异：过敏人群的风险略有增加，而非过敏人群的风险有所降低。结论：过敏与胰腺癌风险之间存在一致的关联，这些结果表明，过敏反应相关基因变异与胰腺癌之间的关联值得进一步研究。
BACKGROUND Several studies in epidemiology indicate that risk of pancreatic cancer is reduced in individuals with allergies. Although genes have been identified that are critical in allergic response, polymorphisms in these genes have not been studied in relation to risk of pancreatic cancer. We hypothesized that variants in these genes are related to risk. METHODS We investigated the association of allergies and pancreatic cancer in a hospital-based case-control study with 405 cases and 212 controls. In a subgroup of 149 cases and 135 controls, we studied the association of variants in IL-4 (C-589T, G3017T) and IL-4R alpha (Gln576Arg) with allergies and with risk of pancreatic cancer. RESULTS We found reduced risk of pancreatic cancer associated with allergies, with adjusted odds ratios of 0.58 (95% CI 0.40-0.84) for any allergies, 0.45 (95% CI 0.29-0.70) for hay fever, and 0.43 (95% CI 0.23-0.80) for animals. The minor allele at each locus studied was associated with reduced risk of allergies in controls, leading us to hypothesize that they would be associated with increased risk of pancreatic cancer. Overall, there was no association between the genotypes studied and risk of pancreatic cancer. In analyses within strata defined by presence or absence of allergies, there were differences in risk associated with genotype for IL-4 G3017T: there was slightly increased risk among those with allergies and reduced risk among those without allergies. CONCLUSIONS The consistent association of allergies with risk of pancreatic cancer and these results suggest that associations between variants in genes related to allergic response and pancreatic cancer warrant further study.