Androgen-insensitive rats are defeminised by their testes
Androgen-insensitive rats are defeminised by their testes
复制标题
雄激素不敏感的大鼠的睾丸使其去女性化
DOI：
10.1038/279238a0
复制
发表时间：
1979
期刊：
影响因子：
64.8
通讯作者：
Kathie L. Olsen
中科院分区：
文献类型：
--
作者：
Kathie L. Olsen;Kathie L. Olsen
一些染色体为XY的男性人类1、小鼠2、3和大鼠4生来就有阴道、阴唇和阴蒂，而不是阴囊和阴茎。这些个体中的雌性表型的表达被认为是由于对睾丸分泌的雄激素不敏感。这种现象被称为雄激素不敏感综合征或睾丸女性化。通常，雄激素不敏感的人被识别并采用女性性别身份5。另一方面，雄激素不敏感的大鼠似乎无法在成年后表现出高度的女性化行为，即使给予雌激素和孕酮6，7。它在这里表明，雄激素不敏感的雄性大鼠能够响应卵巢激素与女性的性行为的显示，如果他们在出生时被阉割，但不是出生后10天被阉割。虽然这些大鼠在生殖分化方面对睾丸分泌物不敏感，但出生后最初几天内睾丸的存在使性行为的神经基质发生分化。
SOME chromosomal XY male humans1, mice2,3 and rats4 are born with a vagina, labia and clitoris instead of scrotum and penis. The expression of the female phenotype in these individuals is thought to be due to an insensitivity to androgenic hormones which are secreted by the testes. This phenomenon has been termed the androgen-insensitivity syndrone or testicular feminisation. Typically, androgen-insensitive humans are identified and adopt a female gender identity5. Androgen-insensitive rats, on the other hand, seem to be incapable of showing a high degree of feminine behaviour in adulthood even when given oestrogen and progesterone6,7. It is shown here that androgen-insensitive male rats are capable of responding to ovarian hormones with the display of feminine sexual behaviour if they are castrated at birth but not when castrated 10 d after birth. Although these rats are insensitive to their testicular secretions in terms of genital differentiation, the neural substrate of sexual behaviour is differentiated by the presence of testes during the first few days after birth.