DO THE REDUCTIONS IN SOCIAL-INTERACTION PRODUCED BY PICROTOXIN AND PENTYLENETETRAZOLE INDICATE ANXIOGENIC ACTIONS
DO THE REDUCTIONS IN SOCIAL-INTERACTION PRODUCED BY PICROTOXIN AND PENTYLENETETRAZOLE INDICATE ANXIOGENIC ACTIONS
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DOI：
10.1016/0028-3908(84)90113-8
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发表时间：
1984-01-01
影响因子：
4.7
通讯作者：
LISTER, RG
中科院分区：
文献类型：
--
作者：
FILE, SE;LISTER, RG
在焦虑的社交互动测试中，观察了印防己毒素(2和4 mg/kg)和戊四氮(PTZ 5、10和20 mg/kg)的影响。印防己毒素(2毫克/公斤)显著减少了积极的社会互动，但没有伴随着运动活动的减少，这表明有引发焦虑的作用。印防己毒素(4毫克/千克)和戊四唑(20毫克/千克)减少了75%的社会互动和40%的运动活动。尽管运动活动的减少很可能是社交互动水平非常低的次要因素，但对导致焦虑的效应进行明确的解释是不可能的。注射印防己毒素后，血浆中皮质酮浓度的增加与该药物引起焦虑的情况一致。氯氮卓酮(5 mg/kg)可显著逆转注射印防己毒素(4 mg/kg)和戊四氮(20 mg/kg)所致的社会交往和运动能力的下降。
The effects of picrotoxin (2 and 4 mg/kg) and of pentylenetetrazol (PTZ 5, 10 and 20 mg/kg) were examined in a social-interaction test of anxiety. Picrotoxin (2 mg/kg) caused a significant reduction in active social interaction, without a concomitant reduction in motor activity, indicating an anxiogenic action. Picrotoxin (4 mg/kg) and pentylenetrazole (20 mg/kg) reduced social interaction by > 75% and motor activity by 40%. Although it is likely that the reduction in motor activity is secondary to the very low levels of social interaction, an unambiguous interpretation of an anxiogenic effect is not possible. Increased concentrations of corticosterone in plasma following administration of picrotoxin were consistent with the drug being anxiogenic. Chlordiazepoxide (5 mg/kg) significantly reversed the reductions in social interaction and locomotor activity following injection of picrotoxin (4 mg/kg) and PTZ (20 mg/kg).