LINKAGE DISEQUILIBRIUM IN FINITE POPULATIONS
LINKAGE DISEQUILIBRIUM IN FINITE POPULATIONS
复制标题
DOI：
10.1007/bf01245622
复制
发表时间：
1968-01-01
影响因子：
5.4
通讯作者：
ROBERTSON A
中科院分区：
文献类型：
--
作者：
HILL W G;ROBERTSON A
从理论上探讨了群体大小（N）和重组率（c）对一对基因座间连锁不平衡（D）的影响。研究了两种情况：（i）两个位点对适合度没有影响;（ii）两个位点均表现出杂合子优势，但不表现上位性，如果群体最初处于连锁平衡，则D的平均值在近交时保持为零，但D 2的平均值增加到最大值，然后下降，直到两个位点都达到固定。连锁越紧密，选择越大，则D2的平均值达到最大值的时间越晚，其值越大。还研究了分离系内配子群体中基因频率r的相关性。结果发现，对于一系列的选择强度和初始基因频率，r2的平均值几乎完全由N c和时间，测量成正比于N。这些结果的影响，在自然群体中的连锁不平衡的观察进行了讨论。
A theoretical investigation has been made of the influence of population size (N) and recombination fraction (c) on linkage disequilibrium (D) between a pair of loci. Two situations were studied: (i) where both loci had no effect on fitness and (ii) where they showed heterozygote superiority, but no epistacy.If the populations are initially in linkage equilibrium, then the mean value ofDremains zero with inbreeding, but the mean ofD2increases to a maximum value and decreases until fixation is reached at both loci. The tighter the linkage and the greater the selection, then the later is the maximum in the mean ofD2reached, and the larger its value. The correlation of gene frequencies,r, in the population of gametes within segregating lines was also studied. It was found that, for a range of selection intensities and initial gene frequencies, the mean value ofr2was determined almost entirely byN cand time, measured proportional toN.The implication of these results on observations of linkage disequilibrium in natural populations is discussed.