Oxytocin enhances brain function in children with autism
Oxytocin enhances brain function in children with autism
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DOI：
10.1073/pnas.1312857110
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发表时间：
2013-12-24
影响因子：
11.1
通讯作者：
Pelphrey, Kevin A.
中科院分区：
文献类型：
--
作者：
Gordon, Ilanit;Vander Wyk, Brent C.;Pelphrey, Kevin A.
鼻内注射催产素（OT）后，我们通过功能性MRI测量了17名高功能自闭症谱系障碍（ASD）儿童在判断社会（眼睛）和非社会（车辆）有意义的图片时大脑活动的变化。OT增加了纹状体、额中回、内侧前额叶皮质、右眶额皮质和左上级颞沟的活动。在纹状体、脑桥核、左后上级颞沟和左前运动皮层中，OT在社会判断时增加活动，在非社会判断时减少活动。唾液OT浓度从基线到给药后30分钟的变化与右杏仁核和眶额皮质在社会与非社会判断过程中的活动增加呈正相关。因此，OT可能会选择性地影响自闭症儿童对社会有意义的刺激的突显性和享乐性评价，从而促进社会协调。这些发现进一步发展了神经生理系统水平的理解机制，OT可以增强ASD儿童的社会功能。
Following intranasal administration of oxytocin (OT), we measured, via functional MRI, changes in brain activity during judgments of socially (Eyes) and nonsocially (Vehicles) meaningful pictures in 17 children with high-functioning autism spectrum disorder (ASD). OT increased activity in the striatum, the middle frontal gyrus, the medial prefrontal cortex, the right orbitofrontal cortex, and the left superior temporal sulcus. In the striatum, nucleus accumbens, left posterior superior temporal sulcus, and left premotor cortex, OT increased activity during social judgments and decreased activity during nonsocial judgments. Changes in salivary OT concentrations from baseline to 30 min postadministration were positively associated with increased activity in the right amygdala and orbitofrontal cortex during social vs. nonsocial judgments. OT may thus selectively have an impact on salience and hedonic evaluations of socially meaningful stimuli in children with ASD, and thereby facilitate social attunement. These findings further the development of a neurophysiological systems-level understanding of mechanisms by which OT may enhance social functioning in children with ASD.