Astrocyte-mediated control of cerebral microcirculation
Astrocyte-mediated control of cerebral microcirculation
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DOI：
10.1016/s0166-2236(03)00141-3
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发表时间：
2003-07-01
影响因子：
15.9
通讯作者：
Nedergaard, M
中科院分区：
文献类型：
--
作者：
Anderson, CM;Nedergaard, M
星形胶质细胞Ca2+动力学的表征已经是一个相当重视的主题超过十年。然而，直到最近，星形胶质细胞Ca2+信号的生理意义才开始变得清晰。几项研究表明，星形胶质细胞Ca2+水平响应于神经元输入而升高，这反过来又影响突触活动。Zonta等人描述了星形胶质细胞Ca2+信号传导的新功能，其中神经元诱导的星形胶质细胞Ca2+升高可导致血管周围星形胶质细胞末端足分泌血管舒张物质，从而改善局部血流。这一发现代表了我们对星形胶质细胞功能和活动依赖性脑血流调节机制的认识的突破。
Characterization of astrocyte Ca2+ dynamics has been a topic of considerable emphasis for more than a decade. Only recently, however, has the physiological significance of astrocyte Ca2+ signaling started to become clear. Several studies have shown that astrocyte Ca2+ levels become elevated in response to neuronal input and that this, in turn, influences synaptic activity. A novel function of astrocyte Ca2+ signaling has been described by Zonta et al, whereby neuron-induced astrocyte Ca2+ elevations can lead to secretion of vasodilatory substances from perivascular astrocyte end-feet, resulting in improved local blood flow. This finding represents a breakthrough in our knowledge both of astrocyte function and of the mechanism of activity-dependent cerebral blood flow regulation.