BOLD asynchrony elucidates tumor burden in IDH-mutated gliomas.
BOLD asynchrony elucidates tumor burden in IDH-mutated gliomas.
复制标题
BOLD 异步阐明了 IDH 突变神经胶质瘤的肿瘤负荷。
DOI：
10.1093/neuonc/noab154
复制
发表时间：
2022
期刊：
影响因子：
15.9
通讯作者：
Grinband,Jack
中科院分区：
文献类型：
--
作者：
Petridis,PetrosD;Horenstein,CraigI;Pereira,Brianna;Wu,PeterB;Samanamud,Jorge;Marie,Tamara;Boyett,Deborah;Sudhakar,TejaswiD;Sheth,SameerA;McKhann,GuyM;Sisti,MichaelB;Bruce,JeffreyN;Canoll,Peter;Grinband,Jack
背景胶质瘤是最常见的原发性脑肿瘤，具有高度侵袭性，往往是致命的。IDH突变的神经胶质瘤对成像特别具有挑战性，并且目前没有临床上可接受的方法用于鉴定这些肿瘤中肿瘤负荷的程度。这种不确定性对临床医生提出了挑战，他们必须平衡治疗肿瘤的需要，同时使健康的大脑免受医源性损伤。本研究的目的是探讨使用静息态血氧水平依赖（BOLD）功能磁共振成像（fMRI）检测胶质瘤相关血管动力学异常的可行性，以区分肿瘤与健康脑。护理术前成像以及回波平面静息态BOLD功能MRI。将BOLD成像和标准护理成像的信号强度与总细胞数（H&E）、肿瘤密度（TNM）和肿瘤体积（TNM）的细胞计数进行比较。（IDH 1和Sox 2）、细胞增殖（Ki 67）和神经元密度（NeuN）。（H&E，P= 4 × 10-5），肿瘤密度（IDH1，P= 4 × 10 ~（-5）; Sox 2，P= 3 × 10-5），细胞增殖（Ki 67，P= .002），与神经元密度呈负相关（NeuN，P= 1 × 10-4）.结论静息态BOLD fMRI测量的血管动力学的不同步性，与肿瘤负荷相关，并提供IDH突变胶质瘤中肿瘤边界的放射学描绘。
BackgroundGliomas comprise the most common type of primary brain tumor, are highly invasive, and often fatal. IDH-mutated gliomas are particularly challenging to image and there is currently no clinically accepted method for identifying the extent of tumor burden in these neoplasms. This uncertainty poses a challenge to clinicians who must balance the need to treat the tumor while sparing healthy brain from iatrogenic damage. The purpose of this study was to investigate the feasibility of using resting-state blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to detect glioma-related asynchrony in vascular dynamics for distinguishing tumor from healthy brain.MethodsTwenty-four stereotactically localized biopsies were obtained during open surgical resection from ten treatment-naïve patients with IDH-mutated gliomas who received standard-of-care preoperative imaging as well as echo-planar resting-state BOLD fMRI. Signal intensity for BOLD asynchrony and standard-of-care imaging was compared to cell counts of total cellularity (H&E), tumor density (IDH1 & Sox2), cellular proliferation (Ki67), and neuronal density (NeuN), for each corresponding sample.ResultsBOLD asynchrony was directly related to total cellularity (H&E,P= 4 × 10–5), tumor density (IDH1,P= 4 × 10–5; Sox2,P= 3 × 10–5), cellular proliferation (Ki67,P= .002), and inversely related to neuronal density (NeuN,P= 1 × 10–4).ConclusionsAsynchrony in vascular dynamics, as measured by resting-state BOLD fMRI, correlates with tumor burden and provides a radiographic delineation of tumor boundaries in IDH-mutated gliomas.