Immunity and repression in bacteriophages P1 and P7.
Immunity and repression in bacteriophages P1 and P7.
复制标题
噬菌体 P1 和 P7 的免疫和抑制。
DOI：
10.1007/978-3-642-67717-5_3
复制
发表时间：
1980
影响因子：
--
通讯作者：
Scott,JR
中科院分区：
文献类型：
--
作者：
Scott,JR
The temperate phage P1 (Bertani1951) is a large complex phage whose double stranded DNA has a molecular weight of 66 × 106(YunandVapnek1977). The DNA in the phage particles is terminally redundant and cyclically permuted (IkedaandTomizawa1968). P1 is best known for its ability to perform generalized transduction (Lennox1955;IkedaandTomizawa1965) and has been used extensively as a tool inEscherichia coligenetics. Because of its broad host range, P1 also serves as a transducing phage for other bacterial species (Goldberget al. 1974;KaiserandDworkin1975). Phage P1 is the prototype of a class of temperate phages whose prophage is not integrated into the host chromosome (IkedaandTomizawa1968), and thus the strategies it uses to maintain lysogeny may differ from those used by integrative prophages. The P1 prophage is a plasmid (of molecular weight 61 × 106:YunandVapnek1977) and is maintained at about one copy per cell nucleoid (IkedaandTomizawa1968). So, in addition to regulation of transcription, the P1 prophage must also regulate its replication. P1 has all of the characteristics of both a temperate phage and a plasmid. Like other temperate phages, P1 prophage is repressed for production of lytic phage functions and a P1 lysogen exhibits immunity to superinfection by other P1 phage. Like other plasmids, the P1 prophage exhibits incompatibility with related plasmids, i. e., it cannot coexist in the same cell with another member of the same incompatibility group (Hedgeset al. 1975). The mechanism for this phenomenon is not yet understood.
