Effects of midazolam on insulin secretion from isolated rat pancreatic islets of Langerhans.
Effects of midazolam on insulin secretion from isolated rat pancreatic islets of Langerhans.
复制标题
咪达唑仑对离体大鼠朗格汉斯胰岛胰岛素分泌的影响。
DOI：
10.1093/bja/70.2.221
复制
发表时间：
1993
影响因子：
9.8
通讯作者：
S. Howell
中科院分区：
文献类型：
--
作者：
J. Desborough;P. Jones;S. Persaud;S. Howell
分离，培养的大鼠胰岛的朗格汉斯细胞培养在培养基中含有葡萄糖2或20 mmol升-1，并与葡萄糖补充咪达唑仑10，100或1000 ng ml-1。葡萄糖20 mmol L-1，加入去甲肾上腺素10 μ mol L-1作为对照。与去甲肾上腺素相反，咪达唑仑不抑制葡萄糖诱导的胰岛素分泌。去甲肾上腺素10 μ mol L-1抑制葡萄糖20 mmol L-1的分泌至基础值（P < 0.001）。
Isolated, cultured rat pancreatic islets of Langerhans were incubated in medium containing glucose 2 or 20 mmol litre-1 and with glucose supplemented with midazolam 10, 100 or 1000 ng ml-1. Glucose 20 mmol litre-1 with the addition of noradrenaline 10 mumol litre-1 was used as a control. In contrast with noradrenaline, midazolam did not inhibit glucose-induced insulin secretion. Noradrenaline 10 mumol litre-1 inhibited secretion to basal values in response to glucose 20 mmol litre-1 (P < 0.001).