Assessing abnormal rod photoreceptor activity with the a-wave of the electroretinogram: Applications and methods
Assessing abnormal rod photoreceptor activity with the a-wave of the electroretinogram: Applications and methods
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DOI：
10.1007/bf02584080
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发表时间：
1996-01-01
影响因子：
1.4
通讯作者：
Birch, David G.
中科院分区：
文献类型：
--
作者：
Hood, Donald C.;Birch, David G.
疾病对光转导的影响可以通过将杆 a 波的前缘拟合到具有定量表达的高能闪光来评估。获得杆受体活性的两个参数：S（灵敏度）和Rm（最大响应）。在本研究中，研究了这些参数的含义以及改变它们的条件示例。此外，还开发了一种新的协议来获取这些参数。首先在黑暗中呈现一组三到五个白色闪光，然后在适应场（30 cd/m2）上呈现。从暗适应响应中减去光适应响应就得到了孤立的杆状 a 波响应。基于单一白色闪光能量开发了临床方案。无需使用任何方程，就可以通过该单一闪光能量确定疾病是否导致 S 和/或 Rm 发生变化。
The impact of a disease on phototransduction can be assessed by fitting the leading edge of the rod a-wave to high-energy flashes with a quantitative expression. Two parameters of rod receptor activity are obtained, S (sensitivity) and Rm (maximum response). In this study, the meaning of these parameters and examples of conditions that change them were examined. In addition, a new protocol was developed for obtaining these parameters. A set of three to five white flashes were first presented in the dark and then on an adapting field (30 cd/m2). Subtracting the light-adapted responses from the dark-adapted responses yielded isolated rod a-wave responses. A clinical protocol was developed based on a single white flash energy. It is possible to determine whether a disease is producing a change in S and/or Rm with this single flash energy without the use of any equations.