Evidence for a dopaminergic mechanism for the prolactin inhibitory effect of atrial natriuretic factor.
Evidence for a dopaminergic mechanism for the prolactin inhibitory effect of atrial natriuretic factor.
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DOI：
10.1159/000124922
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发表时间：
1988-03
影响因子：
4.1
通讯作者：
W. K. Samson;Rene Bianchi;Randy J. Mogg
中科院分区：
文献类型：
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作者：
W. K. Samson;Rene Bianchi;Randy J. Mogg
将 2 nmol 心房钠尿因子 (ANF) 输注到意识清醒、睾丸切除的雄性大鼠的第三脑室中，会显着抑制催乳素 (PRL) 的分泌。通过预先使用多巴胺受体拮抗剂多潘立酮治疗可以防止这种效应。此外，在 ANF 输注后给予多潘立酮可逆转抑制作用。抑制酪氨酸羟化酶活性后，PRL 抑制作用也不存在。这些结果表明，ANF 至少部分通过与内源性多巴胺能系统的相互作用发挥中枢作用，并进一步表明该肽在下丘脑内具有有效的神经调节作用。
Infusion of 2 nmol atrial natriuretic factor (ANF) into the third cerebroventricle of conscious, orchidectomized male rats results in a significant inhibition of prolactin (PRL) secretion. This effect is prevented by prior treatment with the dopamine receptor antagonist, domperidone. Furthermore, domperidone reverses the inhibitory effect when given after ANF infusion. The PRL-inhibiting effect is absent as well following inhibition of tyrosine hydroxylase activity. These results suggest that ANF acts centrally at least in part via an interaction with endogenous dopaminergic systems and further suggests potent neuromodulatory actions of the peptide within the hypothalamus.