Role of plant CBP/p300-like genes in the regulation of flowering time
Role of plant CBP/p300-like genes in the regulation of flowering time
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DOI：
10.1111/j.1365-313x.2006.02939.x
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发表时间：
2007-01-01
期刊：
影响因子：
7.2
通讯作者：
Noh, Bosl
中科院分区：
文献类型：
--
作者：
Han, Soon-Ki;Song, Ju-Dong;Noh, Bosl
CREB 结合蛋白 (CBP) 及其同源物 p300 具有组蛋白乙酰转移酶活性，并作为控制动物分化和发育的基因表达调节中的关键转录共激活因子发挥作用。然而，CBP/p300 样基因在植物中的作用尚未阐明。在这里，我们发现拟南芥 CBP/p300 样基因通过影响主要花抑制因子 FLOWERING LOCUS C (FLC) 的表达来促进开花。虽然动物 CBP 和 p300 通常充当共激活剂，但拟南芥 CBP/p300 样蛋白是 FLC 负调节所必需的。这种 CBP/p300 介导的 FLC 抑制可能涉及独立于 FLC 染色质内组蛋白修饰的可逆蛋白质乙酰化。
CREB-binding protein (CBP) and its homolog p300 possess histone acetyltransferase activity and function as key transcriptional co-activators in the regulation of gene expression that controls differentiation and development in animals. However, the role of CBP/p300-like genes in plants has not yet been elucidated. Here, we show that Arabidopsis CBP/p300-like genes promote flowering by affecting the expression of a major floral repressor FLOWERING LOCUS C (FLC). Although animal CBP and p300 generally function as co-activators, Arabidopsis CBP/p300-like proteins are required for the negative regulation of FLC. This CBP/p300-mediated FLC repression may involve reversible protein acetylation independent of histone modification within FLC chromatin.