5-HT2 Receptor Distribution Shown by [18F] Setoperone PET in High-Functioning Autistic Adults
5-HT2 Receptor Distribution Shown by [18F] Setoperone PET in High-Functioning Autistic Adults
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DOI：
10.1176/appi.neuropsych.11080202
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发表时间：
2012-03-01
影响因子：
2.9
通讯作者：
Bauman, Margaret L.
中科院分区：
文献类型：
--
作者：
Beversdorf, David Q.;Nordgren, Richard E.;Bauman, Margaret L.
血清素能系统与情绪行为紊乱有关。自闭症的特点是情绪信息处理受损。血清素能 (5-HT) 系统也与大脑发育密切相关，在自闭症患者中观察到血清素的大脑合成异常。此外，据报道，自闭症患者的全血和血小板血清素升高。作者在体内检查了自闭症患者的中枢神经系统血清素系统。在这项针对 6 名高功能自闭症成人和 10 名匹配对照参与者的初步研究中，通过 [F-18] setoperone 结合的 PET 成像使 5-HT2 受体可视化。当年龄共变时，自闭症受试者的丘脑 [F-18] setoperone 结合少于对照组，但在其他领域没有差异达到显着性。还观察到丘脑结合与语言障碍史之间存在负相关关系。需要进一步的研究来更清楚地了解 5-HT 系统在自闭症中的作用。 （《神经精神病学和临床神经科学杂志》2012 年；24：191-197）
The serotonergic system is implicated in disordered emotional behavior. Autism is characterized by impaired processing of emotional information. The serotonergic (5-HT) system is also critically involved in brain development, and abnormal brain synthesis of serotonin is observed in autism. Furthermore, whole blood and platelet serotonin have been reported to be elevated in autism. The authors examined the CNS serotonin system in autism in vivo. 5-HT2 receptors were visualized by PET imaging of [F-18] setoperone-binding in this pilot study of 6 high-functioning autistic adults and 10 matched-control participants. Autism subjects had less thalamic [F-18] setoperone binding than controls, when covaried for age, but no difference reached significance in other areas. A negative relationship between thalamic binding and history of language impairment was also observed. Further studies will be needed to gain a clearer picture of the role of the 5-HT system in autism. (The Journal of Neuropsychiatry and Clinical Neurosciences 2012; 24:191-197)