Measurement of lung volume and ventilation distribution with an ultrasonic flow meter in healthy infants
Measurement of lung volume and ventilation distribution with an ultrasonic flow meter in healthy infants
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DOI：
10.1183/09031936.02.00226002
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发表时间：
2002-10-01
影响因子：
24.3
通讯作者：
Frey, U
中科院分区：
文献类型：
--
作者：
Schibler, A;Hall, GL;Frey, U
婴儿小气道疾病的特点是肺容量异常和通气分布不均匀。介绍了一种使用脉冲超声流量计的惰性示踪气体冲洗/冲洗技术，用于测量自主呼吸和非镇静婴儿的功能剩余容量（FRC）和通气分布。用脉冲超声通过流量计的主流发送，可以计算呼吸气体的流量、体积和MM。六氟化硫被用作示踪气体。在机械肺模型（体积范围53-188 mL）和12名健康婴儿（年龄38.3+/-9.2天，平均+/-SD）中，评估了该技术的准确性和重复性。计算肺泡平均稀释数（AMDN）、肺清除率延迟（PCD）等通气分布指标。肺模型体积测量的平均误差为0.58%（方差系数（CV） 1.3%）。FRC在正常婴儿中处于低预测范围（18.0+/-2.0 mL.kg(-1)），高度可重复性（5.5+/-1.7%受试者内CV）。AMDN为1.63+/-0.15，PCD为52.9+/-11.1%。使用六氟化硫冲洗/冲洗和超声波流量计测量功能剩余容量和通气分布，在肺模型和健康、自主呼吸和未使用镇静剂的婴儿中证明是高度准确和可重复的。
Small airway disease in infants is characterised by abnormal lung volume and uneven ventilation distribution. An inert tracer gas washin/washout technique using a pulsed ultrasonic flow meter is presented to measure functional residual capacity (FRC) and ventilation distribution in spontaneously breathing and unsedated infants.With a pulsed ultrasound sent through the main stream of the How meter, flow, volume and MM of the breathing gas can be calculated. Sulphur hexafluoride was used as a tracer gas. In a mechanical lung model (volume range 53-188 mL) and in 12 healthy infants (aged 38.3+/-9.2 days; mean+/-SD) accuracy and reproducibility of the technique was assessed. Indices of ventilation distribution 'such as alveolar-based mean dilution number (AMDN) and pulmonary clearance delay (PCD) were calculated.Mean error of volume measurement in the lung model was 0.58% (coefficient of variance (CV) 1.3%). FRC was in the low predicted range for normal infants (18.0+/-2.0 mL.kg(-1)) and highly reproducible (5.5+/-1.7% intra-subject CV). AMDN was 1.63+/-0.15 and PCD was 52.9+/-11.1%.Measurement of functional residual capacity and ventilation distribution using a sulphur hexafluoride washin/washout and an ultrasonic flow meter proved to be highly accurate and reproducible in a lung model and in healthy, spontaneously breathing and unsedated infants.