NEURAL MECHANISMS OF THE REFLEX INHIBITION AND EXCITATION OF GASTRIC-MOTILITY ELICITED BY ACUPUNCTURE-LIKE STIMULATION IN ANESTHETIZED RATS
NEURAL MECHANISMS OF THE REFLEX INHIBITION AND EXCITATION OF GASTRIC-MOTILITY ELICITED BY ACUPUNCTURE-LIKE STIMULATION IN ANESTHETIZED RATS
复制标题
DOI：
10.1016/0168-0102(93)90105-y
复制
发表时间：
1993-10-01
影响因子：
2.9
通讯作者：
UCHIDA, S
中科院分区：
文献类型：
--
作者：
SATO, A;SATO, Y;UCHIDA, S
以麻醉大鼠为实验对象，观察针刺样刺激胃各节段区对胃运动的影响。将直径340 μ m的针刺针插入皮肤及皮下肌肉，深度4 ~ 5mm，每秒左右扭动1次，持续60 s。用球囊法测定幽门区胃运动。对腹部和下胸部进行类似针灸的刺激会抑制胃的运动，当对四肢进行刺激时，胃的运动往往会兴奋，在所有刺激皮肤和肌肉的情况下，只刺激皮肤，只刺激下面的肌肉。胃对腹部刺激的抑制性反应伴随着胃交感传出神经活动的增加，并通过切断通往胃的交感神经分支或胸下脊神经而消除。腹部刺激增强了下胸椎传入神经的活动。胃对后爪刺激的兴奋性反应伴随着胃迷走神经传出神经活动的增加，并被双侧迷走神经或股神经和坐骨神经的切断所消除。后爪刺激增强股神经和坐骨传入神经的活动。在脊椎动物中，腹部刺激引起的胃抑制反应存在，后爪刺激不产生任何胃反应。我们认为，针刺样刺激腹部引起的胃抑制反应是一种反射反应。其传入神经通路由腹部皮神经和肌肉传入神经组成，传出神经通路为胃交感神经，其反射中枢在脊髓内。针刺样刺激后爪引起的胃兴奋性反应也是一种反射反应。其传入神经通路由后爪皮传入神经和肌肉传入神经组成，传出神经通路为胃迷走传出神经，其反射中枢需要脑在场。此外，静脉注射纳洛酮（0.4 ~ 4 mg/kg）对兴奋性和抑制性胃反射反应没有影响，提示内源性阿片类药物不参与胃反射。
The effects of acupuncture-like stimulation of the various segmental areas on gastric motility were examined in anesthetized rats. An acupuncture needle (diameter 340 mu m) was inserted into the skin and underlying muscles at a depth of 4-5 mm and was twisted right and left once every second for 60 s. Gastric motility in the pyloric region was measured with the balloon method. Gastric motility was inhibited by acupuncture-like stimulation applied to the abdomen and lower chest region, and was often excited when the limbs were stimulated, in all cases in which stimuli were delivered to the skin and muscles, the skin alone, and the underlying muscles alone. The inhibitory gastric response to abdominal stimulation was accompanied by an increase in the activity of the gastric sympathetic efferent nerve and was abolished by severance of either the sympathetic nerve branches to the stomach or the lower thoracic spinal nerves. The abdominal stimulation enhanced the activity of the lower thoracic spinal afferent nerves. The excitatory gastric response to hindpaw stimulation was accompanied by an increase in the activity of the gastric vagal efferent nerve and was abolished by severance of either the bilateral vagi or the femoral and sciatic nerves. The hindpaw stimulation enhanced the activity of the femoral and sciatic afferent nerves. In the spinalized animals, the inhibitory gastric response elicited by abdominal stimulation was present, and the hindpaw stimulation did not produce any gastric response.We conclude that the inhibitory gastric response elicited by acupuncture-like stimulation of the abdomen is a reflex response. Its afferent nerve pathway is composed of abdominal cutaneous and muscle afferent nerves, the efferent nerve pathway is the gastric sympathetic nerve, and its reflex center is within the spinal cord. The excitatory gastric response elicited by acupuncture-like stimulation of a hindpaw is also a reflex response. Its afferent nerve pathway is composed of hindpaw cutaneous and muscle afferent nerves, the efferent nerve pathway is the gastric vagal efferent nerve, and its reflex center requires the presence of the brain. Furthermore, the excitatory and the inhibitory gastric reflex responses were not influenced by i.v. administration of naloxone (0.4-4 mg/kg), suggesting that endogenous opioids are not involved in the present reflexes.