Paradoxical stimulation of both lipocortin and prostaglandin production in human amnion cells by dexamethasone.
Paradoxical stimulation of both lipocortin and prostaglandin production in human amnion cells by dexamethasone.
复制标题
地塞米松对人羊膜细胞中脂皮质素和前列腺素产生的矛盾刺激。
DOI：
10.1016/0006-291x(88)90569-4
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发表时间：
1988
影响因子：
3.1
通讯作者：
Varticovski,L
中科院分区：
文献类型：
--
作者：
Mitchell,MD;Lytton,FD;Varticovski,L
糖皮质激素通过诱导脂皮质素的形成来抑制前列腺素的生物合成。在人羊膜细胞中，地塞米松引起前列腺素产生的浓度依赖性增加，并提高细胞内脂皮质素1浓度。地塞米松也可以加强表皮生长因子（EGF）诱导的刺激前列腺素的产生。EGF单独或与地塞米松组合增加羊膜细胞中脂皮质素1的形成。人羊膜细胞可能为糖皮质激素、脂皮质素和类花生酸生物合成之间的相互作用提供独特的见解。
Glucocorticoids inhibit prostaglandin biosynthesis by inducing the formation of lipocortins. In human amnion cells dexamethasone elicited a concentration-dependent increase in prostaglandin production and raised intracellular lipocortin 1 concentrations. Dexamethasone could also potentiate the epidermal growth factor (EGF)-induced stimulation of prostaglandin production. EGF alone or in combination with dexamethasone increased lipocortin 1 formation in amnion cells. Human amnion cells may provide a unique insight into interactions between glucocorticoids, lipocortin and eicosanoid biosyn-thesis.