Androgen regulation of secretory component mRNA levels in the rat lacrimal gland.
Androgen regulation of secretory component mRNA levels in the rat lacrimal gland.
复制标题
雄激素对大鼠泪腺分泌成分 mRNA 水平的调节。
DOI：
10.1007/978-1-4615-2417-5_38
复制
发表时间：
1994
影响因子：
--
通讯作者：
Sullivan,DA
中科院分区：
文献类型：
--
作者：
Gao,J;Lambert,RW;Wickham,LA;Sullivan,DA
眼睛分泌免疫系统的功能表达严重依赖于分泌成分(SC)，1聚合的IgA受体。2这种由泪腺上皮细胞产生的糖蛋白控制分泌性IgA(SLGA)抗体到眼表面的转移，从而SIgA防御微生物和有毒化合物。1鉴于SC在眼粘膜免疫中的关键作用，我们的研究试图阐明这种泪液蛋白的合成和分泌过程。这类研究表明：[a]大鼠泪腺组织产生的SC具有明显的性别差异(即雄性腺体产生的SC明显多于雌性)；3，4和[b]SC的合成受内分泌、神经和免疫系统的独特调节。5.6因此，SC的合成受到雄激素、血管活性肠肽、β-肾上腺素能激动剂(如异丙肾上腺素)、白介素Lα(El-Lα)、白细胞介素1受体激动剂(IL-1β，IL-Iβ)、肿瘤坏死因子-α(Tumor Necker-α)和前列腺素E2(Prostaglandin E2，PGE_2)的刺激，而被胆碱能激动剂(如卡巴胆碱)抑制。此外，这些与性别相关的和神经内分泌免疫对泪液SC合成的影响似乎是眼睛所独有的，因为其他粘膜部位的SC的产生：[a]可能没有表现出性别二型性(例如，唾液、呼吸、肠道、D.A.Sullivan，未发表的数据)；以及[b]可能被雌激素、孕激素、糖皮质激素、催乳素、甲状腺激素、P物质和γ-干扰素(γ-干扰素)增强或抑制，这取决于组织，7-13这些药物对泪腺分泌细胞合成的SC没有明显的影响。
The functional expression of the secretory immune system of the eye is critically dependent upon secretory component (SC),1the polymeric IgA receptor.2This glycoprotein, which is produced by lacrimal gland epithelial cells, controls the transfer of secretory IgA (slgA) antibodies to the ocular surface, whereupon sIgA defends against microbial agents and toxic compounds.1Given this pivotal role of SC in ocular mucosal immunity, our research has sought to elucidate the processes involved in the synthesis and secretion of this lacrimal protein. Such studies have demonstrated that: [a] SC production by rat lacrimal tissue displays distinct, gender-related differences (i.e. glands of males produce significantly more SC than those of females);3,4and [b] SC synthesis by rat lacrimal acinar cells is uniquely regulated by the endocrine, nervous and immune systems.5.6Thus, SC production is stimulated by androgens, vasoactive intestinal peptide (VIP), β-adrenergic agonists (e.g. isoproterenol), interleukm-lα (EL-lα), interleukin-1β (IL-Iβ), tumor necrosis factor-α (TNF-α) and prostaglandin E2(PGE2), and suppressed by cholinergic agonists (e.g. carbachol choline). Moreover, these gender-associated and neuroendocrinimmune effects on lacrimal SC synthesis appear to be unique to the eye, given that SC production by other mucosal sites: [a] may show no sexual dimorphism (e.g. salivary, respiratory, intestinal, D.A. Sullivan, unpublished data); and [b] may be enhanced or inhibited, depending upon the tissue, by estrogens, progestins, glucocorticoids, prolactin, thyroxine, substance P and γ-interferon (γ-IFN),7–13which agents have no demonstrable impact on the constitutive SC Output by lacrimal acinar cells.6