Cardiac magnetic resonance imaging in small animal models of human heart failure
Cardiac magnetic resonance imaging in small animal models of human heart failure
复制标题
DOI：
10.1016/s1361-8415(03)00011-2
复制
发表时间：
2003-09-01
影响因子：
10.9
通讯作者：
Bauer, WR
中科院分区：
文献类型：
--
作者：
Nahrendorf, M;Hiller, KH;Bauer, WR
本研究的目的是测试电影磁共振成像（MRI）评估梗死大鼠和小鼠心脏的可行性，并将结果与现有方法进行比较。这些模型已被证明可以预测患者心力衰竭的发生和预防。在研究干预改变重塑过程的研究中，电影MRI的价值得到了检验。MRI检测左心室体积、质量、心肌梗死大小和心输出量。MRI后测定左室湿重。采用常规血流动力学方法，通过电磁流量计和压力-容积曲线测定大鼠心输出量和左室容积。梗死面积由组织学决定。mri获得的mi尺寸（18.5+/-2%）小于组织学发现的(22.8+/-2.5%,p
The aim of this study was to test the feasibility of cine magnetic resonance imaging (MRI) for assessment of the infarcted rat and mouse heart and to compare the results with established methods. These models have been proven to predict genesis and prevention of heart failure in patients. The value of cine MRI was tested in studies investigating interventions to change the course of the remodeling process. MRI was performed for determination of left ventricular (LV) volumes and mass, myocardial infarct (MI) size and cardiac output. LV wet weight was determined after MRI. Rats underwent conventional hemodynamic measurements for determination of cardiac output and LV volumes by electromagnetic flowmeter and pressure-volume curves. Infarct size was determined by histology. MRI-acquired MI-size (18.5+/-2%) was smaller than that found by histology (22.8+/-2.5%, p