Effects of an ethanolic extract of mulberry fruit on blood pressure and vascular remodeling in spontaneous hypertensive rats
Effects of an ethanolic extract of mulberry fruit on blood pressure and vascular remodeling in spontaneous hypertensive rats
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DOI：
10.1080/10641963.2018.1469645
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发表时间：
2019-01-01
影响因子：
12.3
通讯作者：
Choi, Bok Hee
中科院分区：
文献类型：
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作者：
Park, Sang Woong;Shin, Kyung Chul;Choi, Bok Hee
桑树(Morus Alba)自古以来就被用于东方传统医药。最近，有报道桑树通过eNOS信号通路产生降压作用。然而，桑叶的降压作用机制尚不完全清楚。此外，桑树对血管重塑事件的影响也不明确，如增生，这是高血压和动脉硬化发病机制中的重要病因学。在这里，我们假设桑树果醇提物(EMF)对血管重塑有有益的作用，并产生降压作用。在自发性高血压大鼠(SHR)上观察了6周口服电磁场的效果。动物分为4组：正常血压对照组(Wistar京都大鼠)、未治疗的SHR、低剂量(100 mg/kg)EMF治疗的SHR和高剂量(300 mg/kg)EMF治疗的SHR。我们的结果表明，电磁场饮食以剂量依赖的方式使SHR的高血压正常化，这是通过防止血管中膜肥厚和血管高反应性而实现的。在我们的实验设置中，电动势饮食对血管内皮细胞的功能没有实质性的影响。综上所述，我们认为桑树果可通过其对血管收缩和血管增殖的作用，作为高血压患者降压的食物补充。
Mulberry (Morus alba) has been used in traditional oriental medicine since ages. Recently, it has been reported that mulberry produces hypotensive effects through the eNOS signaling pathway. However, the mechanism underlying the hypotensive effects of mulberry is not entirely clear. Moreover, the effects of mulberry on vascular remodeling events such as hyperplasia, an important etiology in the pathogenesis of hypertension and arteriosclerosis, are also ambiguous. Here, we hypothesized that an ethanolic extract of mulberry fruit (EMF) has beneficial effects on vascular remodeling and produces hypotensive effects. The effects of a 6-week oral administration of EMF were examined in spontaneously hypertensive rats (SHRs). The animals were divided into four groups: normotensive control (Wistar Kyoto rats), non-treated SHR, low-dose (100 mg/kg) EMF-treated SHR, and high-dose (300 mg/kg) EMF-treated SHR. Our results showed that the EMF-diet normalizes hypertension in SHRs in a dose-dependent manner, by preventing smooth muscle proliferation, thickening of the tunica media, and vascular hyper-reactivity. The endothelial functions were not substantially affected by the EMF diet in our experimental setting. In conclusion, we suggest that the mulberry fruit could act as a food supplement for reducing blood pressure in hypertensive subjects through its effects on smooth muscle proliferation and vascular contractility.