Insights into bactericidal action of surface-attached poly(vinyl-N-hexylpyridinium) chains
Insights into bactericidal action of surface-attached poly(vinyl-N-hexylpyridinium) chains
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DOI：
10.1023/a:1015584423358
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发表时间：
2002-05-01
影响因子：
2.7
通讯作者：
Klibanov, AM
中科院分区：
文献类型：
--
作者：
Lin, J;Tiller, JC;Klibanov, AM
聚乙烯载玻片表面纳米涂层二氧化硅和衍生的长链聚（乙烯基-N-己基吡啶）成为永久杀菌：它杀死90-99%（空气和水）的野生型和人类病原体金黄色葡萄球菌耐药菌株。所产生的材料对表达多药耐药泵的菌株同样致命，这是对阳离子防腐剂的唯一已知耐药机制。
The surface of polyethylene slides nanocoated with silica and derivatized with long-chain poly(vinyl-N-hexylpyridinium) becomes permanently bactericidal: it kills 90-99% of (both airborne and waterborne) wild-type and antibiotic-resistant strains of the human pathogen Staphylococcus aureus. The material created was similarly lethal to strains expressing multidrug resistance pumps, the only known mechanism of resistance to cationic antiseptics.