Hallmarks of Caenorhabditis elegans N-glycosylation:: complexity and controversy
Hallmarks of Caenorhabditis elegans N-glycosylation:: complexity and controversy
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DOI：
10.1016/s0300-9084(03)00041-5
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发表时间：
2003-01-01
期刊：
影响因子：
3.9
通讯作者：
Dell, A
中科院分区：
文献类型：
--
作者：
Haslam, SM;Dell, A
秀丽隐杆线虫已成为广泛应用于分子细胞生物学应用的模式生物之一，越来越多地被糖生物学家使用。然而，一个主要的问题是缺乏对这种生物体中蛋白质连接的多糖结构的了解。近年来，几个小组公布了结构数据，特别是N-葡聚糖结构数据。然而，其中一些数据是相互矛盾的。在这篇综述中，我们对所有的N-糖链结构数据进行了严格的评估，并考虑到我们距离定义线虫糖蛋白的目标有多近。(C)2003年版《科学与医学》、《爱思唯尔科学与医学》和《法国生物与生物分子》。版权所有。
Caenorhabditis elegans has become one of the most widely used model organisms for a range of molecular cell biological applications and is being increasingly used by glycobiologists. However, a major problem has been the lack of knowledge of the structure of the protein-linked glycans from this organism. In recent years several groups have published structural data, particularly N-glycan structural data. However, some of these data are contradictory. In this review we critically assess all the N-glycan structural data and consider how close we are in our goal of defining the glycome of C. elegans. (C) 2003 Editions scientifiques et medicales Elsevier SAS and Societe francaise de biochimie et biologic moleculaire. All rights reserved.