Differential Effects of α-Glucosidase Inhibitors on Postprandial Plasma Glucose and Lipid Profile in Patients with Type 2 Diabetes Under Control with Insulin Lispro Mix 50/50
Differential Effects of α-Glucosidase Inhibitors on Postprandial Plasma Glucose and Lipid Profile in Patients with Type 2 Diabetes Under Control with Insulin Lispro Mix 50/50
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DOI：
10.1089/dia.2012.0015
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发表时间：
2012-07-01
影响因子：
5.4
通讯作者：
Miyamori, Isamu
中科院分区：
文献类型：
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作者：
Kimura, Tomoko;Suzuki, Jinya;Miyamori, Isamu
背景资料：α-葡萄糖苷酶抑制剂的累加效应在用速效胰岛素类似物控制的2型糖尿病（T2 D）患者中研究α-GI。招募了36名控制不佳的T2 D患者，并且通过每天三次注射赖脯胰岛素混合物50/50（Mix 50）来控制血糖（PG），以维持空腹PG < 130 mg/dL和2- 100 mg/dL。h餐后PG（PPG）< 180 mg/dL。另一组20例患者随机分配至0.3 mg伏格列波糖或50 mg米格列醇，每隔一天在早餐时给药。另一组16名患者被分配到交叉研究中，在6天的研究期间每天更换每种α-GI。PPG，C-肽，和血脂profile.Results：除了伏格列波糖对PPG没有影响，但米格列醇钝化PPG的上升，并显着降低1-h和2-h餐后C-肽水平相比，Mix 50单独。此外，米格列醇显着降低餐后1小时甘油三酯的上升和残余颗粒样胆固醇的上升，而增加餐后1小时高密度脂蛋白胆固醇和载脂蛋白A-I水平的交叉study.Conclusions：米格列醇似乎有快速的行动，这似乎比赖脯氨酸出现的时间早。米格列醇和Mix 50的组合似乎可有效控制T2 D中的PPG和脂质特征。
Background: The additive effect of alpha-glucosidase inhibitors (alpha-GIs) was investigated in patients with type 2 diabetes (T2D) under control with rapid-acting insulin analog.Subjects and Methods: Thirty-six poorly controlled T2D patients were recruited, and plasma glucose (PG) was controlled by three times daily injection of insulin lispro mix 50/50 (Mix50) to maintain fasting PG < 130 mg/dL and 2-h postprandial PG (PPG) < 180 mg/dL. Another group of 20 patients was randomly assigned to either 0.3 mg of voglibose or 50 mg of miglitol, which was administered at breakfast every other day. Another group of 16 patients was assigned to a crossover study, in which each alpha-GI was switched every day during the 6-day study. PPG, C-peptide, and lipid profile were analyzed.Results: The addition of voglibose had no effect on PPG, but miglitol blunted the PPG rise and significantly decreased 1-h and 2-h postprandial C-peptide levels compared with Mix50 alone. In addition, miglitol significantly decreased the 1-h postprandial triglyceride rise and the remnant-like particle-cholesterol rise, while it increased the 1-h postprandial high-density lipoprotein-cholesterol and apolipoprotein A-I levels in the crossover study.Conclusions: Miglitol appears to have rapid action, which appears earlier than that of lispro. The combination of miglitol and Mix50 seems effective for the control of PPG and lipid profile in T2D.