Decavanadate (V10O286-) and oxovanadates: Oxometalates with many biological activities
Decavanadate (V10O286-) and oxovanadates: Oxometalates with many biological activities
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DOI：
10.1016/j.jinorgbio.2008.11.010
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发表时间：
2009-04-01
影响因子：
3.9
通讯作者：
Crans, Debbie C.
中科院分区：
文献类型：
--
作者：
Aureliano, Manuel;Crans, Debbie C.
十聚钒酸盐种类V10 O286-，也称为十钒酸盐，影响蛋白质、脂质结构和细胞功能，并在体内对氧化应激过程和其他生物学特性显示出一些影响。十钒酸盐在许多生物化学系统中的作用模式至少部分取决于种类的电荷和大小，并且在某些情况下与更简单的氧代钒酸盐种类竞争。含有10个钒原子的橙子十钒酸盐在中性pH下对几种粘土是稳定的物种，但在较高pH下立即转化为结构和功能不同的较低氧代钒酸盐，如单体、二聚体或四聚体。虽然钒的生物效应通常被认为是来自单体钒酸盐或钒基阳离子，但我们在这篇综述中表明，并非所有的效应都可以归因于这些简单的氧钒酸盐形式。尽管背景资料是可获得的，但我以前没有对该主题进行过综述[D. C. Crans，Comments Inorg. Chem. 16 1994）35-76：M。Aureliano（Ed.），生物化学，研究路标出版物，印度喀拉拉邦，2007年]。除了泵，通道和代谢型受体，脂质结构代表潜在的生物靶点;对于decavanadate和一些例子已经报道。十钒酸盐以复杂的方式与所有变构位点中的底物结构域OF中的酶、多磷酸盐、核苷酸和肌醇3-磷酸结合位点相互作用。在线粒体中，钒被证明在体内施用十钒酸盐后积累，除了抑制氧消耗外，十钒酸盐的nM浓度还诱导膜去极化，这表明线粒体可能是十聚体毒性的潜在靶点。十钒酸盐在鱼模型中的体内作用表明，抗氧化应激标记物、脂质过氧化和钒亚细胞分布取决于施用的溶液是否含有十钒酸盐。本文综述了十钒酸盐的生物效应，并强调了在评价钒的生物效应时考虑十钒酸盐的重要性。(C)2008年爱思唯尔公司All rights reserved.
The decameric vanadate species V10O286-, also referred to as decavanadate, impact proteins, lipid structures and cellular function, and show some effects in vivo on oxidative stress processes and other biological properties, The mode of action of decavanadate in many biochemical systems depends, at least in part, on the charge and size of the species and in some cases competes with the simpler oxovanadate species. The orange decavanadate that contains 10 vanadium atoms is a stable species for several clays at neutral pH, but at higher pH immediately converts to the structurally and functionally distinct lower oxovanadates such as the monomer, dimer or tetramer. Although the biological effects of vanadium are generally assumed to (derive from monomeric vandate or the vanadyl cation, we show in this review that not all effects can be attributed to these simple oxovanadate forms. This topic has not previously been I reviewed although background information, is available [D.C. Crans, Comments Inorg. Chem. 16 1994) 35-76: M. Aureliano (Ed.), Vanadium Biochemistry, Research Signpost Publs., Kerala, India, 2007]. In addition to pumps, Channels and metabotropic receptors, lipid structures represent potential biological targets; for decavanadate and some examples have been reported. Decavanadate interact with enzymes, polyphosphate, nucleotide and inositol 3-phosphate binding sites in the substrate domain OF in all allosteric site, in a complex manner. In mitochondria, where vanadium was shown to accumulate following decavanadate in vivo administration, nM concentration of decavanadate induces membrane depolarization in addition to inhibiting oxygen consumption, suggesting that mitochondria may be potential targets for decameric toxicity. In vivo effects of decavanadate in piscine models demonstrated that antioxidant stress markers, lipid peroxidation and vanadium subcellular distribution is dependent Upon Whether or not the, solutions administered contain decavanadate. The present review summarizes the reports oil biological effects of decavanadate and highlights the importance of considering decavanadate in evaluations, of the biological effects of vanadium. (C) 2008 Elsevier Inc. All rights reserved.