Folate status of mothers during pregnancy and mental and psychomotor development of their children at five years of age
Folate status of mothers during pregnancy and mental and psychomotor development of their children at five years of age
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DOI：
10.1542/peds.2004-2189
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发表时间：
2005-09-01
期刊：
影响因子：
8
通讯作者：
Nelson, KG
中科院分区：
文献类型：
--
作者：
Tamura, T;Goldenberg, RL;Nelson, KG
objective.有关母亲怀孕期间叶酸营养状况与其后代智力和精神发育的数据有限。使用现有的数据集从一项研究的影响，产前补锌对儿童神经发育，我们评估了叶酸营养状况的母亲在怀孕期间和他们的孩子的神经发育之间的关联。在妊娠19周、26周和37周时测量母体血液叶酸和总同型半胱氨酸（tHcy）浓度。在平均5.3岁时，355名低社会经济背景的黑人儿童接受了6项测试：差异能力量表，视觉和听觉顺序记忆，诺克斯立方体测试，粗大运动量表和凹槽钉板。比较2组叶酸营养状况较差与充足的母亲之间的测试得分，并根据血液叶酸或tHcy浓度进行分类。两组儿童神经发育测试评分无差异。叶酸营养状况的母亲在怀孕后期的血浆和红细胞叶酸和血浆tHcy浓度进行评估，没有影响他们的孩子在5岁的神经发育。目前尚不清楚我们在低社会经济水平人群中的发现是否可以很容易地外推到其他人群。
Objective. There are limited data relating folate nutritional status of mothers during pregnancy to mental and psychomotor development of their offspring. Using an existing data set from a study on the effect of prenatal zinc supplementation on child neurodevelopment, we evaluated the association between folate nutritional status of mothers during pregnancy and neurodevelopment of their children.Methods. Maternal blood folate and total homocysteine (tHcy) concentrations were measured at 19, 26, and 37 weeks of gestation. At a mean of 5.3 years of age, 355 black children with low-socioeconomic background were given 6 tests: Differential Ability Scales, Visual and Auditory Sequential Memory, Knox Cube Test, Gross Motor Scale, and Grooved Pegboard. The scores of the tests between the 2 groups of mothers with poor versus adequate folate nutritional status classified by blood folate or tHcy concentrations were compared.Results. There were no differences in the test scores of neurodevelopment between the 2 groups.Conclusion. Folate nutritional status of mothers in the later half of pregnancy assessed by plasma and erythrocyte folate and plasma tHcy concentrations had no impact on neurodevelopment of their children at age 5. It is unknown whether our findings in a low-socioeconomic population can be readily extrapolated to other populations.