Regulation of the intestinal epithelial barrier by the apical junctional complex
Regulation of the intestinal epithelial barrier by the apical junctional complex
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DOI：
10.1097/01.mog.0000203864.48255.4f
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发表时间：
2006-03-01
影响因子：
2.5
通讯作者：
Nusrat, A
中科院分区：
文献类型：
--
作者：
Laukoetter, MG;Bruewer, M;Nusrat, A
综述目的上皮细胞间连接是上皮屏障的重要组成部分，在克罗恩病等疾病中受到损害。我们将强调最近的进展，在了解的作用，称为顶端连接复杂的细胞间连接在调节小肠上皮通透性在健康和diseases.Recent调查结果最近的研究表明，作为一个潜在的因素，导致克罗恩病患者的上皮屏障渗漏的AJC的异常调节。上皮通透性增加的后果包括肠组织暴露于管腔抗原/病原体，这反过来影响疾病活动。此外，促炎细胞因子释放到克罗恩病患者的上皮细胞环境中影响顶端连接复合体和上皮屏障功能。这些细胞因子通过促进组分蛋白质的差异内吞作用诱导顶端连接复合物的分解。此外，顶端连接复合物蛋白质的病原体，使用上皮作为门户网站的入口建立疾病在host.Summary上皮顶端连接复合物是重要的，在确定上皮屏障特性。最近的研究强调了促炎细胞因子和顶端连接复合物蛋白的内吞作用对上皮屏障缺陷的贡献。对这一领域理解的不断进步将为肠道疾病提供新的治疗靶点。
Purpose of review Epithelial intercellular junctions are important components of the epithelial barrier and are compromised in disorders such as Crohn's disease. We will highlight recent progress in understanding the role of an intercellular junction referred to as the apical junctional complex in regulating small intestinal epithelial permeability in health and disease.Recent findings Recent studies have implicated aberrant regulation of the AJC as an underlying factor contributing to a leaky epithelial barrier in Crohn's patients. Consequences of increased epithelial permeability include exposure of intestinal tissue to luminal antigens/pathogens which in turn influence disease activity. Furthermore, proinflammatory cytokines released into the milieu of the epithelium in patients with Crohn's disease influence apical junctional complex and epithelial barrier function. Such cytokines induce disassembly of the apical junctional complex by promoting differential endocytosis of component proteins. Additionally, apical junctional complex proteins are targeted by pathogens that use the epithelium as a portal of entry to establish disease in the host.Summary The epithelial apical junctional complex is important in determining epithelial barrier properties. Recent studies have highlighted contribution of proinflammatory cytokines and endocytosis of apical junctional complex proteins to the epithelial barrier defect. Continued advances in understanding of this field will yield new therapeutic targets for intestinal disorders.