METHIONINE-ENKEPHALIN AND BETA-ENDORPHIN LEVELS IN BRAIN, PANCREAS, AND ADRENALS OF DB/DB MICE
METHIONINE-ENKEPHALIN AND BETA-ENDORPHIN LEVELS IN BRAIN, PANCREAS, AND ADRENALS OF DB/DB MICE
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DOI：
10.1210/endo-116-1-328
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发表时间：
1985-01-01
期刊：
影响因子：
4.8
通讯作者：
CHENG, J
中科院分区：
文献类型：
--
作者：
GREENBERG, J;ELLYIN, F;CHENG, J
蛋氨酸-脑啡肽免疫反应性（MEI）和。β。采用特异放射免疫分析法（RIA）测定db/db小鼠和对照小鼠垂体、下丘脑、胰腺和肾上腺的-内啡肽免疫反应性（BEI）。在db/db小鼠的垂体中发现的MEI水平明显高于同窝或背景菌株对照组。胰腺、肾上腺和下丘脑的MEI含量差异无统计学意义。与对照组相比，db/db小鼠垂体内BEI水平有显著差异。在db/db和对照组小鼠所检查的任何其他区域中，未观察到BEI水平的显著差异。显然，db/db小鼠下丘脑-下丘脑轴的阿片肽系统异常，值得进一步研究。本文讨论了这一发现对糖尿病可能病因的意义。
Levels of methionine-enkephalin immunoreactivity (MEI) and .beta.-endorphin immunoreactivity (BEI) were measured by means of a specific RIA [radioimmunoassay] in pituitary, hypothalamus, pancreas and adrenal glands of db/db and control mice. Significantly higher levels of MEI were found in the pituitaries of db/db mice than in either littermate or background strain controls. There was no significant difference in MEI levels in pancreas, adrenal glands and hypothalamus. There was a significant difference in the BEI levels in the pituitaries of db/db mice compared with those in controls. No significant difference in BEI levels was observed between db/db and control mice in any of the other regions examined. Apparently, the opiate peptide system in the hypophyseal-hypothalamic axis of the db/db mouse is abnormal and warrants further investigation. The significance of this finding with respect to the possible etiology of diabetes mellitus is discussed.