THE BRAIN SLICE PREPARATION - A TRIBUTE TO THE PIONEER MCILWAIN,HENRY
THE BRAIN SLICE PREPARATION - A TRIBUTE TO THE PIONEER MCILWAIN,HENRY
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DOI：
10.1016/0165-0270(94)00187-l
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发表时间：
1995-06-01
影响因子：
3
通讯作者：
COLLINGRIDGE, GL
中科院分区：
文献类型：
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作者：
COLLINGRIDGE, GL
亨利·麦克伊勒因其对神经化学学科的重大贡献而被人们铭记。他还发明和建立了脑切片技术，对电生理学产生了深远的影响。本文介绍了他的一些开创性的研究，他设计的方法，准备，手动和机械（使用McIllium组织切碎机），可行的哺乳动物皮层组织切片，并显示这些可以保持在脑切片室。他与Choh-Luh Li（Li and McIllivan，1957）合作首次从脑切片中记录细胞内信息，与Chosaburo Yamamoto（Yamamoto and McIllivan，1966）合作首次研究脑切片中的突触传递。在这些研究中，McIllem开始使用脑切片来研究功能解剖学，研究缺氧和低血糖的影响，进行定量药理学分析和研究突触可塑性：今天继续进行的研究为健康和疾病中大脑的功能提供了重要的见解。
Henry McIlwain is usually remembered for his major contributions to the discipline of neurochemistry. He also had a profound influence on electrophysiology by inventing and establishing the brain slice technique. This article describes some of his pioneering studies where he devised ways of preparing, both manually and mechanically (using the McIlwain tissue chopper), viable slices of mammalian cortical tissue and showed how these could be maintained in a brain slice chamber. His work with Choh-Luh Li (Li and McIlwain, 1957) on the first intracellular recording from brain slices and his work with Chosaburo Yamamoto (Yamamoto and McIlwain, 1966) describing the first study of synaptic transmission in brain slices are highlighted. In these studies, McIlwain started the use of brain slices to investigate functional anatomy, to study the effects of hypoxia and hypoglycaemia, to perform quantitative pharmacological analyses and to study synaptic plasticity: investigations which continue today to provide important insights into the functioning of the brain in health and disease.