Hard spheres in vesicles: Curvature-induced forces and particle-induced curvature
Hard spheres in vesicles: Curvature-induced forces and particle-induced curvature
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DOI：
10.1103/physrevlett.80.409
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发表时间：
1998-01-12
影响因子：
8.6
通讯作者：
Yodh, AG
中科院分区：
文献类型：
--
作者：
Dinsmore, AD;Wong, DT;Yodh, AG
我们探索了膜曲率和非特异性结合的相互作用，这是由于脂质双层囊泡内胶体颗粒之间的排除体积效应所致。我们将两个不同大小的亚微米球体捕获到梨形多层囊泡中，发现较大的球体被钉在囊泡的表面，并朝着曲率增加的方向推进。一个简单的模型预测，坚硬的球体可以在弹性囊泡中诱导形状变化。结果表明，囊泡或孔的形状与其中的颗粒排列之间存在着重要的关系。
We explore the interplay of membrane curvature and nonspecific binding due to excluded-volume effects among colloidal particles inside lipid bilayer vesicles. We trapped submicron spheres of two different sizes inside a pear-shaped, multilamellar vesicle and found the larger spheres to be pinned to the vesicle's surface and pushed in the direction of increasing curvature. A simple model predicts that hard spheres can induce shape changes in flexible vesicles. The results demonstrate an important relationship between the shape of a vesicle or pore and the arrangement of particles within it.