Impairment of central auditory function in Alzheimer's disease.
Impairment of central auditory function in Alzheimer's disease.
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阿尔茨海默病中枢听觉功能受损。
DOI：
10.1080/01688639008400970
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发表时间：
1990
影响因子：
2.2
通讯作者：
P. Fedio
中科院分区：
文献类型：
--
作者：
E. Mohr;C. Cox;J. Williams;T. Chase;P. Fedio
在阿尔茨海默病(AD)患者和一组年龄和教育程度匹配的正常受试者中，使用先前被证明显著改变正常人二分听表现的参数(列表长度、刺激匹配和回忆顺序)，比较了两分听的准确性和偏侧性。阿尔茨海默病患者倾向于表现出本质上相似的表现，但与对照组相比，表现明显差于对照组，这是由于增加了二分表长度和刺激集内容(语义上，v.语音和不匹配的二分项)。此外，这些患者不能选择性地注意右耳或左耳，因此不能增加右耳或左耳相对于自由回忆程序的优势，自由回忆程序是正常受试者很容易掌握的回忆任务顺序。这些结果表明，阿尔茨海默病与参与注意力选择性分配的皮质机制的崩溃有关。
Accuracy and laterality of ear preference on dichotic listening (DL) takes were compared in patients with Alzheimer's disease (AD) and a group of normal subjects, matched for age and education, using parameters (list length, stimulus matching, and order of recall), previously shown to significantly alter DL performance in normals. Alzheimer patients tended to show qualitatively similar, but significantly worse performance compared to controls as a function of increasing dichotic list length as well as stimulus set content (semantically, v. phonemically and unmatched dichotic items). Furthermore, these patients were unable to attend selectively to either the right- or left-ear and thus could not increase right- or left-ear advantages over the free recall procedure, an order of recall task easily mastered by the normal subjects. These results suggest that Alzheimer's disease is associated with a breakdown of cortical mechanisms involved in the selective allocation of attention.