Sex differences in the effect of HbA1c-defined diabetes on a wide range of cardiovascular disease risk factors.
Sex differences in the effect of HbA1c-defined diabetes on a wide range of cardiovascular disease risk factors.
复制标题
DOI：
10.3109/07853890.2015.1127406
复制
发表时间：
2016
影响因子：
4.4
通讯作者：
Sun X
中科院分区：
文献类型：
--
作者：
Du T;Yuan G;Zhou X;Sun X
HbA1c与心血管疾病(CVD)风险之间的性别差异仍然存在争议。我们研究了糖化血红蛋白定义的糖尿病和非糖尿病男性和女性的心血管风险概况。我们利用2009年中国健康与营养调查的数据对7,139名中国成年人进行了横断面分析。HbA1c定义的非糖尿病男性比女性具有更有利的心血管风险概况。然而，与HbA1c定义的糖尿病女性相比，HbA1c定义的糖尿病男性的甘油三酯、低密度脂蛋白-胆固醇、甘油三酯/高密度脂蛋白-胆固醇水平更高，高密度脂蛋白-胆固醇水平更低，内脏肥胖指数(VAI)和脂肪积累产物(LAP)指示的内脏肥胖率更高，甘油三酯和血糖指数(TYG)评估的胰岛素抵抗更多。此外，与非糖尿病男性相比，糖化血红蛋白定义的糖尿病男性在铁蛋白水平上的相对差异比糖尿病女性更大。根据HbA1c定义的糖尿病状态的性别交互作用在甘油三酯、低密度脂蛋白-胆固醇、高密度脂蛋白-胆固醇、甘油三酯/高密度脂蛋白、VAI、LAP、TYG和铁蛋白方面有统计学意义(均P<；0.05)。考虑VAI和/或HOMA-IR并不能消除糖尿病和这些心血管危险因素之间的性别差异。与女性相比，从HbA1c定义的非糖尿病发展到HbA1c定义的糖尿病的男性代谢恶化更严重，内脏脂肪增加更多。
Sex differences in the association of HbA1c and cardiovascular disease (CVD) risk remain controversial. We examined CVD risk profile in HbA1c-defined diabetic and non-diabetic men and women. We conducted a cross-sectional analysis of 7139 Chinese adults using data from the China Health and Nutrition Survey 2009. HbA1c-defined non-diabetic men have a more favorable CVD risk profile than female counterparts. However, HbA1c-defined diabetic men have higher levels of triglyceride, LDL-cholesterol, triglyceride/HDL-cholesterol and lower levels of HDL-cholesterol, be more visceral obese as indicated by visceral adiposity index (VAI) and lipid accumulation product (LAP), and more insulin resistant as assessed by the triglycerides and glucose index (TyG) than HbA1c-defined diabetic women. Furthermore, HbA1c-defined diabetic men showed greater relative differences in ferritin than diabetic women when compared with their non-diabetic counterparts. Statistically significant sex by HbA1c-defined diabetes status interactions were observed for triglyceride, LDL-cholesterol, HDL-cholesterol, triglyceride/HDL cholesterol, VAI, LAP, TyG, and ferritin (all p <0.05). Consideration of VAI or HOMA-IR or both failed to eliminate the sex differences in the association between diabetes and these CVD risk factors. Men who progressed from HbA1c-defined non-diabetes to HbA1c-defined diabetes have greater metabolic deteriorations and put on more visceral adiposity than women.