Personalised computational cardiology: Patient-specific modelling in cardiac mechanics and biomaterial injection therapies for myocardial infarction.
Personalised computational cardiology: Patient-specific modelling in cardiac mechanics and biomaterial injection therapies for myocardial infarction.
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DOI：
10.1007/s10741-016-9528-9
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发表时间：
2016-11
影响因子：
4.6
通讯作者：
Franz T
中科院分区：
文献类型：
--
作者：
Sack KL;Davies NH;Guccione JM;Franz T
生物医学研究中的预测计算模型提供了整合不同数据的潜力，揭示了通过实验方法不易获得的生物机制，并揭示了需要进一步研究的知识空白。计算和诊断技术的最新发展推动了计算模型在复杂性和特异性方面的进步。因此，计算模型可以越来越多地被用作临床中的支持和补充模式——医疗决策和干预措施都是个性化的。尽管有最佳的现代治疗，心肌梗塞和心力衰竭仍然是全球死亡的主要原因之一。新型心肌梗死疗法的开发具有挑战性，但通过预测建模可能会大大促进这种疗法的发展。在这里，我们回顾了患者特异性心脏力学建模的进展，区分了心脏几何形状、肌纤维结构和机械组织特性的特异性。此后，焦点缩小到梗塞心脏的力学和心肌梗塞的治疗，特别关注心肌内生物材料的输送。
Predictive computational modelling in biomedical research offers the potential to integrate diverse data, uncover biological mechanisms that are not easily accessible through experimental methods and expose gaps in knowledge requiring further research. Recent developments in computing and diagnostic technologies have initiated the advancement of computational models in terms of complexity and specificity. Consequently, computational modelling can increasingly be utilised as enabling and complementing modality in the clinic—with medical decisions and interventions being personalised. Myocardial infarction and heart failure are amongst the leading causes of death globally despite optimal modern treatment. The development of novel MI therapies is challenging and may be greatly facilitated through predictive modelling. Here, we review the advances in patient-specific modelling of cardiac mechanics, distinguishing specificity in cardiac geometry, myofibre architecture and mechanical tissue properties. Thereafter, the focus narrows to the mechanics of the infarcted heart and treatment of myocardial infarction with particular attention on intramyocardial biomaterial delivery.