Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications.
Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications.
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DOI：
10.1155/2012/737416
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发表时间：
2012
影响因子：
--
通讯作者：
Lam WL
中科院分区：
文献类型：
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作者：
Enfield KS;Pikor LA;Martinez VD;Lam WL
肺癌生物学传统上集中于蛋白质编码基因的基因组和表观基因组失调，以确定癌基因和肿瘤抑制因子，诊断和治疗靶点。癌症生物学的另一个重要层面以非编码RNA（ncRNA）的形式出现，它们是关键细胞过程（如增殖、RNA剪接、基因调控和细胞凋亡）的主要调控因子。在过去的十年中，microRNAs（miRNAs）已经成为ncRNA癌症研究的前沿，而长链非编码RNA（lncRNAs）的作用正在显现。在这里，我们回顾了肺癌中miRNA和lncRNA的失调机制，可以应用于检测这种改变的技术，以及这些RNA种类的临床潜力。通过了解非编码RNA的失调，它们调节的蛋白质编码基因之间的相互作用，以及这些相互作用如何影响细胞网络和信号通路，可以更好地理解肺癌生物学。
Lung cancer biology has traditionally focused on genomic and epigenomic deregulation of protein-coding genes to identify oncogenes and tumor suppressors diagnostic and therapeutic targets. Another important layer of cancer biology has emerged in the form of noncoding RNAs (ncRNAs), which are major regulators of key cellular processes such as proliferation, RNA splicing, gene regulation, and apoptosis. In the past decade, microRNAs (miRNAs) have moved to the forefront of ncRNA cancer research, while the role of long noncoding RNAs (lncRNAs) is emerging. Here we review the mechanisms by which miRNAs and lncRNAs are deregulated in lung cancer, the technologies that can be applied to detect such alterations, and the clinical potential of these RNA species. An improved comprehension of lung cancer biology will come through the understanding of the interplay between deregulation of non-coding RNAs, the protein-coding genes they regulate, and how these interactions influence cellular networks and signalling pathways.